Contribution of Serological Rapid Diagnostic Tests to the Strategy of Contact Tracing in Households Following SARS-CoV-2 Infection Diagnosis in Children
Autor: | Lorelei Charbonnier, Julie Rouprêt-Serzec, Marion Caseris, Marion Danse, Aurélie Cointe, Laure Cohen, Albert Faye, Naïm Ouldali, Jean Gaschignard |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Pediatrics
medicine.medical_specialty Isolation (health care) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapid diagnostic test RJ1-570 law.invention Serology 03 medical and health sciences 0302 clinical medicine children law 030225 pediatrics Pandemic Quarantine medicine 030212 general & internal medicine Rapid diagnostic test business.industry SARS-CoV-2 Diagnostic test contact-tracing Brief Research Report household RT-PCR-polymerase chain reaction with reverse transcription Pediatrics Perinatology and Child Health business Contact tracing |
Zdroj: | Frontiers in Pediatrics Frontiers in Pediatrics, Vol 9 (2021) |
ISSN: | 2296-2360 |
Popis: | Background: The contact tracing and isolation of contagious individuals are cornerstones in the control of the COVID-19 pandemic. Strategies to identify household contacts who should be isolated around index children that tested positive for SARS-CoV-2 remain to be clarified. We aimed to compare contact tracing strategies around an index child positive for SARS-CoV-2 using serological rapid diagnostic testing (RDT, chromatography immunoassay).Methods: We conducted a contact tracing study in households of index cases children in the Paris region, France, between May 8 and July 27, 2020. We compared two strategies, one using SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) and one combining RT-PCR and serological RDT, initiated once RDT was available. The contacts RT-PCR–/RDT+ were considered to have been previously infected and not requiring quarantine. The primary outcome was the proportion of contacts that could avoid quarantine with the two screening strategies.Results: We included 34 children as index cases. Median age was 7 years. They generated 184 contacts (111 adults, 73 children) tested by RT-PCR: 24/184 (13%) were positive. The strategy combining RDT and RT-PCR was performed in 120/184 contacts (77 adults, 43 children) of 26 index children: 16/120 (13%) were RT-PCR+ and 47/120 (39%) were RDT+. Among the 16 individuals who were RT-PCR+, 14 (87%) were also RDT+. Among the 104 individuals who were RT-PCR–, 33 were RDT+. Hence 33/120 (27%) individuals were not isolated.Conclusions: Following the diagnosis of SARS-CoV-2 infection in children, a strategy combining serological RDT and nasopharyngeal RT-PCR enabled us to identify around one fourth of contacts with past infection and avoid unnecessary quarantine of these individuals. |
Databáze: | OpenAIRE |
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