MDR1 Gene Expression and Treatment Outcome in Acute Myeloid Leukemia
| Autor: | Liselotte Havelec, Klaus Geissler, Klaus Lechner, Peter Bettelheim, Robert Pirker, Peter Valent, Heinz Ludwig, Josef Wallner, Martina Hopfner, R. Scherrer, Werner Linkesch, Oskar A. Haas |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Myeloid Adolescent Drug Resistance Gene Expression physiological processes Leukemia Myelomonocytic Acute Leukemia Promyelocytic Acute Internal medicine Gene expression polycyclic compounds Humans Medicine RNA Neoplasm neoplasms Survival analysis Aged Aged 80 and over business.industry RNA Myeloid leukemia Induction chemotherapy Middle Aged Prognosis medicine.disease Survival Analysis Multiple drug resistance Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Leukemia Monocytic Acute Immunology Female Leukemia Erythroblastic Acute business |
| Zdroj: | JNCI Journal of the National Cancer Institute. 83:708-712 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/83.10.708 |
| Popis: | To prospectively assess the role of MDR1 gene expression in patients with de novo acute myeloid leukemia (AML), levels of MDR1 RNA in blast cells were determined at diagnosis and correlated with treatment outcome in 63 patients. MDR1 RNA levels were negative in 29% and positive in 71% of the patients. The complete remission rate in response to induction chemotherapy was 89% for MDR1 RNA-negative patients and 53% for MDR1 RNA-positive patients (P = .008). Expression of the MDR1 gene was observed in most patients who died early or had resistant disease. Kaplan-Meier curves revealed a decrease in both disease-free survival and overall survival of patients with detectable MDR1 gene expression compared with the disease-free survival and overall survival of MDR1 RNA-negative patients (P = .029 and P = .009, respectively). These data indicate that MDR1 gene expression is an unfavorable prognostic factor and suggest that multidrug resistance is important in AML. |
| Databáze: | OpenAIRE |
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