Pd-Catalyzed Four-Component Sequential Reaction Delivers a Modular Fluorophore Platform for Cell Imaging
| Autor: | Gaurav Joshi, Sandeep Singh, Raj Kumar, Arshad J. Ansari, Praveen Sharma, Ramesh K. Metre, Vijai K. Agnihotri, Devesh M. Sawant, Chanchayya Gupta Chandaluri, Antim K. Maurya |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cytoplasm
Indazoles Fluorophore Staining and Labeling Cytological Techniques Organic Chemistry Synthon Quantum yield Combinatorial chemistry Fluorescence Catalysis Mitochondria chemistry.chemical_compound chemistry Chemical bond Cascade reaction Live cell imaging Cell Line Tumor Quinazolines Humans Amines Palladium Fluorescent Dyes |
| Zdroj: | The Journal of Organic Chemistry. 84:3817-3825 |
| ISSN: | 1520-6904 0022-3263 |
| Popis: | A Pd-catalyzed cascade reaction of four versatile privileged synthons is described. The sequential reaction involves the formation of five new chemical bonds by concatenating three distinct chemical steps. One of the derivatives exhibited absorption in the visible region, fluorescence with a high quantum yield, and excellent photostability. Its application is explored in live cell imaging, which exhibited cytoplasmic and mitochondrial specific staining with no toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|