Association of physical activity with all-cause mortality and incident and prevalent cardiovascular disease among patients with type 1 diabetes: the EURODIAB Prospective Complications Study

Autor: Emmanuel Stamatakis, Nish Chaturvedi, S.M.A.J. Tielemans, Sabita S. Soedamah-Muthu, M. Toeller, J. H. Fuller, M. De Neve
Rok vydání: 2012
Předmět:
Male
Nutrition and Disease
Diabetic Cardiomyopathies
Cross-sectional study
Endocrinology
Diabetes and Metabolism
Disease
Cohort Studies
prevention
Voeding en Ziekte
Epidemiology
Prevalence
Longitudinal Studies
Prospective Studies
risk-factors
Prospective cohort study
Incidence
Incidence (epidemiology)
Middle Aged
density lipoprotein cholesterol
Cardiovascular Diseases
Female
europe
hemoglobin a1c
Cohort study
Adult
medicine.medical_specialty
consensus statement
Motor Activity
Young Adult
Sex Factors
Internal medicine
Diabetes mellitus
retinopathy
Internal Medicine
medicine
Humans
Mortality
Exercise
iddm complications
VLAG
Global Nutrition
standardization
Wereldvoeding
Type 1 diabetes
business.industry
medicine.disease
Cross-Sectional Studies
Diabetes Mellitus
Type 1
Endocrinology
business
Diabetic Angiopathies
Follow-Up Studies
mellitus
Zdroj: Diabetologia 56 (2013) 1
Diabetologia, 56(1), 82-91
ISSN: 1432-0428
0012-186X
DOI: 10.1007/s00125-012-2743-6
Popis: AIMS/HYPOTHESIS: The aim of this study was to examine the association of physical activity (PA) with all-cause mortality and incident and prevalent cardiovascular disease (CVD) among patients with type 1 diabetes. METHODS: The EURODIAB Prospective Complications Study is a cohort including 3,250 male and female patients with type 1 diabetes (mean age 32.7¿±¿10.2 years) from 16 European countries, of whom 1,880 participated in follow-up examinations. In analysis 1 (longitudinal), the association of baseline PA (based on the reported number of hours per week spent in mild, moderate and vigorous PA) with all-cause mortality and incident CVD was examined by performing survival analysis. In analysis 2 (cross-sectional), we focused on the association between PA at follow-up (data on sports, walking distance and regular bicycling) and prevalent CVD by performing logistic regression analysis. Adjustments were made for age, sex, BMI, smoking, consumption of alcohol, consumption of certain nutrients and diabetic complications. RESULTS: Analysis 1 (longitudinal): participation in moderate or vigorous PA once a week or more was borderline inversely associated with all-cause mortality (men and women combined) (HR 0.66, 95% CI 0.42, 1.03) and incident CVD (women only) (HR 0.66, 95% CI 0.40, 1.08). No association was found in men. Analysis 2 (cross-sectional): total PA (indexed by sports, walking, bicycling) and distance walked were inversely associated with prevalent CVD (OR(totalPA) 0.66, 95% CI 0.45, 0.97; and OR(walking) 0.61, 95% CI 0.42, 0.89). CONCLUSIONS/INTERPRETATION: PA showed a borderline inverse association with both all-cause mortality (both sexes) and incident CVD (women only) in patients with type 1 diabetes. Since this is an under-researched clinical population, future longitudinal studies with objective PA measurements are needed to expand on these results.
Databáze: OpenAIRE
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