Silent progression of brain atrophy in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder
| Autor: | Akiyuki Uzawa, Shigeki Hirano, Masahiro Mori, Reiji Aoki, Ryohei Ohtani, Satoshi Kuwabara, Mayumi Muto, Hiroki Masuda, Tomohiko Uchida |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Multiple Sclerosis Cord Grey matter Gastroenterology Cohort Studies Lesion White matter Atrophy Internal medicine medicine Humans Longitudinal Studies Gray Matter Autoantibodies Retrospective Studies Aquaporin 4 Neuromyelitis optica Expanded Disability Status Scale business.industry Multiple sclerosis Neuromyelitis Optica Brain medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Female Surgery Neurology (clinical) medicine.symptom business |
| Zdroj: | Journal of Neurology, Neurosurgery, and Psychiatry |
| ISSN: | 1468-330X 0022-3050 |
| Popis: | ObjectiveTo investigate longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD).MethodsWe investigated the longitudinal brain atrophy rate in patients with aquaporin-4 antibody-positive NMOSD (AQP4+NMOSD) and those with multiple sclerosis (MS) in a retrospective cohort study. Brain volume was calculated with statistical parametric mapping-12.ResultsWe enrolled 36 patients with AQP4+NMOSD and 60 with MS. Patients with NMOSD were older and had a higher Kurtzke’s expanded disability status scale score at baseline MRI compared with those with MS. Disease duration, annual relapse rate and intervals from the last attack and from disease-modifying drugs initiation were not significantly different between the two groups. Lower normalised lesion volume and higher normalised white matter volume were found in patients with NMOSD compared with those with MS at baseline MRI. However, the annualised atrophy rate of normalised brain volume was similar between the NMOSD (median 0.47; IQR 0.75; p=0.49) and MS (median 0.46; IQR 0.84) groups. After adjustment of age and the presence of clinical relapse, no differences of the annualised atrophy rate of normalised brain volume also were found for NMOSD and MS. Patients with AQP4+NMOSD with long cord lesion showed higher annualised atrophy rate of normalised grey matter volume compared with those without long cord lesion.ConclusionsSilent progression of brain atrophy was present in patients with AQP4+NMOSD, as shown in patients with MS, even in the clinically inactive age-matched cases. Subclinical dying back degeneration may explain the brain atrophy in patients with AQP4 +NMOSD. |
| Databáze: | OpenAIRE |
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