Biocompatibility and physicochemical characteristics of alginate–polycation microcapsules

Autor: S.K. Tam, Julie Dusseault, L'Hocine Yahia, G. Langlois, S. Bilodeau, Jean-Pierre Hallé
Rok vydání: 2011
Předmět:
Male
Materials science
Chemical Phenomena
Osmotic shock
Biocompatibility
Alginates
Biomedical Engineering
Biocompatible Materials
Capsules
02 engineering and technology
engineering.material
Biochemistry
Biomaterials
Mice
03 medical and health sciences
Glucuronic Acid
Coating
Materials Testing
Spectroscopy
Fourier Transform Infrared
Polyamines
medicine
Animals
Fourier transform infrared spectroscopy
Peritoneal Cavity
Molecular Biology
030304 developmental biology
0303 health sciences
Hexuronic Acids
Membranes
Artificial
General Medicine
Penetration (firestop)
021001 nanoscience & nanotechnology
Polyelectrolytes
Polyelectrolyte
Mice
Inbred C57BL
Membrane
Chemical engineering
Wettability
engineering
Swelling
medicine.symptom
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Biotechnology
Biomedical engineering
Zdroj: Acta Biomaterialia. 7:1683-1692
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2010.12.006
Popis: There is a need for better understanding of the biocompatibility of alginate-polycation microcapsules based on their physicochemical characteristics. Microcapsules composed of alginate with 44% (IntG) or 71% (HiG) guluronate, gelled with calcium (Ca) or barium (Ba) and coated with poly-L-lysine (PLL) or poly-l-ornithine (PLO), followed by IntG alginate were compared. For microcapsules with an IntG(Ca) gel core, using PLO instead of PLL resulted in less immune cell adhesion after 2 days in C57BL/6J mice. The PLO microcapsules were also characterized by greater hydrophilicity and superior resistance to swelling and damage under osmotic stress. For microcapsules with a PLL membrane, replacing the IntG(Ca) gel core with IntG(Ba) or HiG(Ca) gel resulted in stronger immune responses (p
Databáze: OpenAIRE
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