Immunological alterations in patients with primary tumors in central nervous system
| Autor: | Angela M.V.C. Soares, Tadeu P. Faleiros, Sislaine A. B. Alquati, Roberto Colichio Gabarra, Maria R. Parise-Fortes, Armando Alves, Marcos A. Zanini, Terezinha C. B. Montelli, Mario Rubens Montenegro, Maria Terezinha S. Peraçoli, Anete Ueda |
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| Přispěvatelé: | Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp) |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Adolescent medicine.drug_class CD3 T cell Central nervous system Neurosciences. Biological psychiatry. Neuropsychiatry NK cells Monoclonal antibody Brain tumors Central Nervous System Neoplasms T-Lymphocyte Subsets Immunochemistry Cytotoxic T cell Medicine Humans Child Immunity Cellular biology business.industry Middle Aged Killer Cells Natural medicine.anatomical_structure Neurology Child Preschool Immunology biology.protein brain tumors Female Neurology (clinical) business T cell subsets CD8 K562 cells RC321-571 |
| Zdroj: | Europe PubMed Central Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Arquivos de Neuro-Psiquiatria v.57 n.3A 1999 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO Arquivos de Neuro-Psiquiatria, Vol 57, Iss 3A, Pp 539-546 (1999) |
| Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:19:45Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:29:14Z : No. of bitstreams: 1 2-s2.0-0033182598.pdf: 52714 bytes, checksum: 90ef9008453f8dec5bb6031a9022e97c (MD5) Made available in DSpace on 2014-05-27T11:19:45Z (GMT). No. of bitstreams: 0 Previous issue date: 1999-09-01 Natural killer (NK) cells play an important role in immune surveillance against tumors. The present work aimed to study the cytotoxic activity of NK cells and T cell subsets in peripheral blood of 13 patients with primary tumors in central nervous system (CNS). As controls 29 healthy subjects with the age range equivalent to the patients were studied. The methods employed were: a) determination of cytotoxic activity of NK cells towards K562 target cells, evaluated by single cell-assay; b) enumeration of CD3+ lymphocytes and their CD4+ and CD8+ subsets defined by monoclonal antibodies; c) the identification of tumors were done by histologic and immunochemistry studies. The results indicated that adults and children with tumor in CNS display reduced percentage of total T cells, helper/inducer subset and low helper/suppressor ratio. The cytotoxic activity of NK cells was decreased in patients with CNS tumors due mainly to a decrease in the proportion of target-binding lymphocytes. These results suggest that cytotoxic activity of NK cells may be affected by the immunoregulatory disturbances observed in patients with primary tumors in CNS. Dept. of Microbiology and Immunology Institute of Biosciences State University of São Paulo, Botucatu, São Paulo Dept. of Neurology and Psychiatry School of Medicine State University of São Paulo, Botucatu, São Paulo Department of Pathology School of Medicine State University of São Paulo, Botucatu, São Paulo Depto. de Microbiologia e Imunologia IBB-UNESP, 18618-000 Botucatu SP Depto. de Microbiologia e Imunologia IBB-UNESP, 18618-000 Botucatu SP |
| Databáze: | OpenAIRE |
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