Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection
| Autor: | Eitan S, Miguel Stein, Zvi Bentwich, Z. Weisman, Greenberg Z, A Kalinkovich, Nahmias J |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Lymphocyte T cell Immunology Population Helminthiasis Apoptosis CD8-Positive T-Lymphocytes Biology Lymphocyte Activation medicine.disease_cause Immune system Antigens CD T-Lymphocyte Subsets medicine Humans Immunology and Allergy Lymphocytes education education.field_of_study CD28 Original Articles T lymphocyte Immune dysregulation CD4 Lymphocyte Count medicine.anatomical_structure Chronic Disease Biomarkers CD8 |
| Zdroj: | Clinical and Experimental Immunology. 114:414-421 |
| ISSN: | 1365-2249 0009-9104 |
| Popis: | SUMMARYWe have previously reported the presence of marked immune dysregulation with a dominant Th2 profile, in a population of Ethiopian immigrants (ETH) in Israel heavily infected with helminths. In order to characterize better this immune dysregulation we studied by flow cytometry the expression of several activation markers on peripheral T cell populations, and lymphocyte apoptosis, in blood samples obtained from 63 ‘new’ ETH (recently arrived), 18 ‘old’ ETH (> 5 years since immigration) and 34 non-Ethiopian Israelis. The main findings in the ‘new’ ETH group in comparison with the non-Ethiopian controls were: (i) decreased CD4 and increased CD8 lymphocyte counts; (ii) elevated levels of activated T cells (CD3, CD4 and CD8) expressing HLA-DR; (iii) decreased levels of ‘naive’ CD4+ cells (CD45RA+), with increased levels of ‘memory’ CD4+ cells (CD45RO+); (iv) decreased numbers of CD28+ CD8+ lymphocytes; (v) marked increase in lymphocyte apoptosis. These T cell alterations and activation profile remained unchanged in 10 ‘new’ ETH in whom the helminth infections persisted for 6–11 months. In contrast, in 18 ‘old’ ETH, without helminth infections, the T cell activation profile was within the normal range. These findings suggest that chronic helminth infections may have a profound effect on the immune system of the host that disappears after eradication of these infections and adjustment to the new environment. It should therefore be taken into consideration for every immunomodulation therapy and especially in vaccine design and trials, in regions endemic for helminth infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|