SLIME: robust, high-speed 3D microvascular mapping
| Autor: | Meredith Broberg, Andrew M. Rollins, Michael W. Jenkins, Yehe Liu, Michiko Watanabe |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
genetic structures Computer science Contrast Media lcsh:Medicine Cubic Millimeter Article 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Optical coherence tomography Optical clearing Physical Conditioning Animal medicine Animals lcsh:Science Multidisciplinary medicine.diagnostic_test Physical conditioning Extramural lcsh:R eye diseases Disease Models Animal 030104 developmental biology Fetal Alcohol Spectrum Disorders Microvessels Nanoparticles lcsh:Q sense organs Tomography Tomography Optical Coherence 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-37313-z |
| Popis: | Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes, providing a promising tool for investigating organ level microvascular abnormalities in large cohorts. |
| Databáze: | OpenAIRE |
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