Acute effect of vagus nerve stimulation (VNS) on brain function
| Autor: | Bernhard T. Baune, Andreas Wollbrink, Joachim Gross, Erhan Kavakbasi, Ruth Fellmeth |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Vagus Nerve Stimulation
medicine.medical_treatment Alpha (ethology) Stimulation 03 medical and health sciences 0302 clinical medicine Monoaminergic medicine Premovement neuronal activity Humans Biological Psychiatry Depressive Disorder Major medicine.diagnostic_test business.industry Brain Vagus Nerve Magnetoencephalography Middle Aged medicine.disease 030227 psychiatry Vagus nerve Psychiatry and Mental health Female business Treatment-resistant depression Neuroscience 030217 neurology & neurosurgery Vagus nerve stimulation |
| Zdroj: | Journal of psychiatric research. 141 |
| ISSN: | 1879-1379 |
| Popis: | Introduction VNS is a non-pharmalogical neuromodulatory treatment option for difficult-to-treat depression. A pulse generator implanted in the left chest area is connected to an electrode that is wrapped around the left vagal nerve. It is presumed, that the vagal afferent network modulates neuronal activity in key monoaminergic structures. Methods We performed MEG recording during active stimulation of the left vagal nerve. Our patient was a 60 years old female treated with VNS since December 2019 due to unipolar major depression. Results MEG recording and analysis were possible despite stimulation signals and the metal stimulation systems. We saw a reproducible reduction of the 10-Hz-alpha amplitude after the end of the 30 s stimulation period in wide-spread areas including parieto-occipital cortex where alpha oscillations are prominently generated. During stimulation, however, alpha oscillations remained unaffected. These findings could be reproduced in a second measurement. Conclusion Increased alpha power was linked to depressive states and alterations of cortical activity. A reduction may indicate cortical activation by stimulation of the vagal nerve as a possible mechanism of action of VNS in depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect