Monoamine Oxidase-A Genetic Variations Influence Brain Activity Associated with Inhibitory Control: New Insight into the Neural Correlates of Impulsivity
| Autor: | Maria Cecilia Gioia, Angela Magariello, Luca Passamonti, Leandro Provinciali, Olivier Gallo, Francesco Fera, Antonio Cerasa, Maria Muglia, Giuseppe Nicoletti, Aldo Quattrone |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Impulsivity Adolescent Genotype Prefrontal Cortex Minisatellite Repeats Serotonergic MAO-A Imaging Genetics Extrastriate cortex medicine Humans Allele Prefrontal cortex Monoamine Oxidase Alleles Biological Psychiatry Visual Cortex Brain Mapping Polymorphism Genetic biology medicine.diagnostic_test fMRI Brain Genetic Variation DNA Magnetic Resonance Imaging serotonin Oxygen Monoamine neurotransmitter medicine.anatomical_structure Impulsive Behavior biology.protein medicine.symptom Monoamine oxidase A Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Biological psychiatry (1969) 59 (2006): 334–340. doi:10.1016/j.biopsych.2005.07.027 info:cnr-pdr/source/autori:Passamonti L; Fera F; Magariello A; Cerasa A; Gioia MC; Muglia M; Nicoletti G; Gallo O; Provinciali L; Quattrone A/titolo:Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity/doi:10.1016%2Fj.biopsych.2005.07.027/rivista:Biological psychiatry (1969)/anno:2006/pagina_da:334/pagina_a:340/intervallo_pagine:334–340/volume:59 |
| ISSN: | 0006-3223 |
| Popis: | Background Previous evidence has shown that genetic variations in the serotonergic system contribute to individual differences in personality traits germane to impulse control. The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. High-activity allele carriers have higher enzyme expression, lower amine concentration, and present higher scores on behavioral measures of impulsivity than low-activity allele carriers. Methods We studied the relationship of this polymorphism to brain activity elicited by a response inhibition task (Go/NoGo task), using blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging in 24 healthy men. Results Direct comparison between groups revealed a greater BOLD response in the right ventrolateral prefrontal cortex (Brodmann’s area [BA] 45/47) in high-activity allele carriers, whereas a greater response in the right superior parietal cortex (BA 7) and bilateral extrastriate cortex (BA 18) was found in low-activity allele carriers. Conclusions These data suggest that a specific genetic variation involving serotonergic catabolism can modulate BOLD response associated with human impulsivity. |
| Databáze: | OpenAIRE |
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