Decreased platelet serotonin levels in systemic lupus erythematosus
| Autor: | Carole A. Dorsch, John Meyerhoff |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Serotonin Systemic blood Platelet aggregation Platelet Aggregation Immunology Black People White People Rheumatology Adrenal Cortex Hormones Internal medicine Active disease medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Pharmacology (medical) Platelet Lupus erythematosus business.industry Plasma levels Middle Aged medicine.disease beta-Thromboglobulin Thrombocytopenia Endocrinology Female Kidney Diseases Platelet Granule business |
| Zdroj: | Arthritis and rheumatism. 24(12) |
| ISSN: | 0004-3591 |
| Popis: | Platelet serotonin levels were measured in 41 patients with systemic lupus erythematosus (SLE) and 36 normal controls. SLE patients had significantly lower mean serotonin levels (243 +/- 131 versus 414 +/- 175 ng/10(9) platelets, P less than 0.001); the lowest levels occurred in those patients with active disease. No differences in mean platelet serotonin levels were found when we compared patients with or without a history of renal disease, thrombocytopenia, or neuropsychiatric involvement. Decreased release of platelet granule constituents, as measured by plasma levels of the alpha-granule protein, beta-thromboglobulin. |
| Databáze: | OpenAIRE |
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