Association of Enhanced Limbic Response to Threat With Decreased Cortical Facial Recognition Memory Response in Schizophrenia
| Autor: | Raquel E. Gur, Jeffrey N. Valdez, James Loughead, Steven J. Siegel, Ruben C. Gur, Christian G. Kohler, Kosha Ruparel, Daniel H. Wolf, Theodore D. Satterthwaite |
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| Rok vydání: | 2010 |
| Předmět: |
Facial expression
medicine.medical_specialty medicine.diagnostic_test Cognition Schizoaffective disorder Audiology Affect (psychology) medicine.disease Article Psychiatry and Mental health Limbic system medicine.anatomical_structure Schizophrenia Brief Psychiatric Rating Scale medicine Functional magnetic resonance imaging Psychiatry Psychology |
| Zdroj: | American Journal of Psychiatry. 167:418-426 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/appi.ajp.2009.09060808 |
| Popis: | ObjectiveRecognition memory of faces is impaired in patients with schizophrenia, as is the neural processing of threat-related signals, but how these deficits interact to produce symptoms is unclear. The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia. MethodBlood-oxygen-level-dependent response was examined by means of functional magnetic resonance imaging (3 Tesla) in healthy comparison subjects (N=21) and in patients with schizophrenia (N=12) or schizoaffective disorder, depressed type (N=4), during a two-choice recognition task that used images of human faces. Each target face, previously displayed with a threatening or nonthreatening affect, was displayed with neutral affect. Responses to successful recognition and responses to the effect of previously threatening versus nonthreatening affect were evaluated, and correlations with symptom severity (total Brief Psychiatric Rating Scale score) were exami... |
| Databáze: | OpenAIRE |
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