The combined action of omega-3 polyunsaturated fatty acids and grape proanthocyanidins on a rat model of diet-induced metabolic alterations
| Autor: | Jara Pérez-Jiménez, Marta Romeu, Eunice Molinar-Toribio, Núria Taltavull, Isabel Medina, Gabriel Dasilva, Josep Lluís Torres, Sara Ramos-Romero |
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| Přispěvatelé: | Ministerio de Ciencia e Innovación (España), Consejo Superior de Investigaciones Científicas (España), Secretaría Nacional de Ciencia y Tecnología (Panamá) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Leptin 0301 basic medicine medicine.medical_specialty food.ingredient Docosahexaenoic Acids Adipose tissue Biology Rats Inbred WKY 03 medical and health sciences chemistry.chemical_compound food Internal medicine medicine Animals Insulin Proanthocyanidins Vitis Triglycerides Adiposity Metabolic Syndrome chemistry.chemical_classification 030109 nutrition & dietetics Adiponectin Triglyceride Body Weight food and beverages General Medicine Glucagon Eicosapentaenoic acid Ghrelin Diet Rats Disease Models Animal Cholesterol Endocrinology Eicosapentaenoic Acid chemistry Docosahexaenoic acid Grape seed extract Dietary Supplements Female lipids (amino acids peptides and proteins) Food Science Polyunsaturated fatty acid |
| Popis: | 8 pages, 3 figures It has been suggested that food components such as ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and (poly)phenols counteract diet-induced metabolic alterations by common or complementary mechanisms. To examine the effects of a combination of ω-3 PUFAs and (poly)phenols on such alterations, adult Wistar-Kyoto rats were fed an obesogenic high-fat high-sucrose diet supplemented, or not, for 24 weeks with: eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) 1 : 1 (16.6 g kg(-1) feed); proanthocyanidin-rich grape seed extract (GSE, 0.8 g kg(-1) feed); or EPA/DHA 1 : 1 + GSE. Body weight, feed intake, and plasma glucose were evaluated every 6 weeks, while adipose tissue weight, insulin, glucagon, ghrelin, leptin, adiponectin, cholesterol, and triglycerides were evaluated at the end of the experiment. ω-3 PUFAs reduced plasma leptin and cholesterol levels, but did not modify diet-induced perigonadal fat or plasma insulin levels; while GSE increased plasma triglyceride levels. The combined action of ω-3 PUFAs and the proanthocyanidins reduced plasma insulin and leptin, as well as partially prevented perigonadal fat accumulation. While separate supplementation with ω-3 PUFAs or grape proanthocyanidins may not counteract all the key metabolic changes induced by a high-energy-dense diet, the combination of both supplements reverts altered insulin, leptin and triglyceride levels to normal. This research was supported by the Spanish Ministry of Science and Innovation (through grants AGL2009-12374-C03-01, -02 and -03; and AGL2013-49079-C2-1,2-R). The Panamanian Government (SENACYT/IFRHU) and Spanish Research Council (CSIC) awarded graduate fellowships to E. M.-T. and G. D., respectively. The ISCIII is acknowledged for a “Sara Borrell” postdoctoral contract to J. P.-J. (CD09/00068). |
| Databáze: | OpenAIRE |
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