Synthesis of N-(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald–Hartwig Cross-Coupling
| Autor: | Hichem Ben Jannet, Mouad Alami, Manel Hassine, Nour-Eddine Ghermani, Samir Messaoudi |
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| Přispěvatelé: | Université de Monastir - University of Monastir (UM), Institut Galien Paris-Sud (IGPS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Tropine
010405 organic chemistry Stereochemistry Organic Chemistry convolvine chemistry.chemical_element Sequence (biology) Tropane [CHIM.CATA]Chemical Sciences/Catalysis 010402 general chemistry Convolvulus dorycnium 01 natural sciences tropane Catalysis Palladium catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Buchwald-Hartwig reaction Palladium |
| Zdroj: | SYNTHESIS SYNTHESIS, Georg Thieme Verlag, 2019, ⟨10.1055/s-0039-1690238⟩ |
| ISSN: | 0039-7881 1437-210X |
| Popis: | International audience; The present study describes the isolation of convolvine from the roots of the Tunisian plant Convolvulus dorycnium L. and it's synthesis through a four-steps sequence starting from tropine. Then, an efficient synthesis of N-(het)aryl tropanes derivativesby a sequence of a palladium-catalyzed N-arylationof convolvine has been established. This strategyenabled an access to unknown tropane scaffolds of biological interests. |
| Databáze: | OpenAIRE |
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