Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2)

Autor:	Siavash Mashayekh, Lee M. Stunkard, Maryline Kienle, Irimpan I. Mathews, Chaitan Khosla
Rok vydání:	2022
Předmět:	Humans Pyrimidine Nucleotides Uridine Kinase Uridine Biochemistry
Zdroj:	Biochemistry. 61:2261-2266
ISSN:	1520-4995 0006-2960
DOI:	10.1021/acs.biochem.2c00451
Popis:	Pyrimidine nucleotide biosynthesis in humans is a promising chemotherapeutic target for infectious diseases caused by RNA viruses. Because mammalian cells derive pyrimidine ribonucleotides through a combination of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c927f48e3caadc07ccd33fca9e30f76e https://doi.org/10.1021/acs.biochem.2c00451 Zobrazit plný text záznamu