IL-24 contributes to skin inflammation in Para-Phenylenediamine-induced contact hypersensitivity
| Autor: | Rémi Opsomer, Younes Achouri, Astrid Van Belle, Magali de Heusch, Peggy Raynaud, Laure Dumoutier, Guy Warnier, Perrine Cochez, Emilie Hendrickx, Paméla Chéou, Marie Baeck, Jean-Christophe Renauld, Lisa Pointner |
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| Přispěvatelé: | Ludwig Institute for Cancer Research, Université Catholique de Louvain = Catholic University of Louvain (UCL), Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Experimental Medicine Unit, Department of Dermatology [Brussels, Belgium], Université Catholique de Louvain = Catholic University of Louvain (UCL)-Saint-Luc University Hospital [Brussels, Belgium], UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/MEXP - Médecine expérimentale, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de dermatologie |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biopsy [SDV]Life Sciences [q-bio] lcsh:Medicine Acanthosis Phenylenediamines Interleukin 22 Mice 0302 clinical medicine lcsh:Science Coloring Agents Receptor ComputingMilieux_MISCELLANEOUS Skin Mice Inbred BALB C Multidisciplinary medicine.diagnostic_test Middle Aged 3. Good health Dermatitis Allergic Contact Cytokines medicine.symptom Adult Inflammation [SDV.BC]Life Sciences [q-bio]/Cellular Biology Article Exocytosis 03 medical and health sciences medicine Animals Humans Allergic contact dermatitis Aged business.industry Interleukins lcsh:R Receptors Interleukin Immunoglobulin E medicine.disease Mice Inbred C57BL Disease Models Animal 030104 developmental biology Immunology Leukocyte Common Antigens lcsh:Q business 030217 neurology & neurosurgery Spongiosis |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-018-38156-4⟩ Scientific Reports, Vol. 9, no. 1, p. 1852 [1-11] (2019) Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Para-Phenylenediamine (PPD) is an aromatic amine used in hair dyes and in temporary black henna tattoos, which is a frequent cause of allergic contact dermatitis (ACD). ACD is a skin inflammatory reaction characterized by modifications such as spongiosis, exocytosis and acanthosis. The aim of this study is to characterize the expression and the role of IL-20-related cytokines, including IL-19, IL-20, IL-22 and IL-24, in ACD. The expression of IL19, IL20, IL22 and IL24 is increased in affected skin from PPD allergic patients compared with uninvolved skin. In addition, the expression of these cytokines positively correlates with clinical symptoms. To assess their role in ACD, we set up a mouse model of PPD-induced allergic contact dermatitis and we showed that, in contrast to Il22-deficient mice, Il22ra1-, Il20rb- and Il24-deficient mice are partially protected against development of PPD-induced contact hypersensitivity. These mice have decreased ear thickening and less acanthosis compared with WT mice after PPD treatment. In addition, the absence of IL-22R, IL-20R2 or IL-24 affects the recruitment of neutrophils into the skin but not the total IgE production. Taken together, these results demonstrate the implication of IL-24 via the IL-20R type II receptor in the inflammatory process of ACD. |
| Databáze: | OpenAIRE |
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