Effect of intratumoral application of methotrexate in vivo on frequency of micronuclei in peripheral blood lymphocytes
| Autor: | Tanja Novakovic, Olivera Milosevic-Djordjevic, Darko Grujicic, Dragoslav Marinkovic, Slobodan Jankovic, Slobodan Arsenijevic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Pathology Micronuclei Gastroenterology lcsh:RC254-282 Injections In vivo Internal medicine medicine Lymphocytes business.industry Significant difference Antagonist Myoma Hematology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Peripheral blood Intralesional Methotrexate Oncology Total dose Micronucleus test Uterine Neoplasms business medicine.drug |
| Zdroj: | Archive of Oncology, Vol 11, Iss 1, Pp 1-4 (2003) |
| ISSN: | 0354-7310 |
| Popis: | BACKGROUND: Methotrexate is a cytostatic drug belonging to the group of antimetabolites; it is an antagonist of folic acid with an intensive application in gynecology practice. METHODS: The frequency of micronuclei (MN) in peripheral blood lymphocytes of 30 patients with myoma uteri was analyzed before and after intratumoral application of methotrexate (MTX) in total dose from 50 to 115 mg. Analysis of micronuclei was performed by the application of cytokinesis-block technique (CB). RESULTS: Average frequency of MN in lymphocytes of patients before the therapy was 4.6?0.4 MN/1000 analyzed cells. After the completion of therapy with six separate doses during six consecutive menstrual average frequency of MN increased 1.5 times (7.0?0.6) in comparison to control frequency before the therapy. Statistically significant difference (p |
| Databáze: | OpenAIRE |
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