Comparison of Gd DTPA-BMA (Omniscan) versus Gd HP-DO3A (ProHance) Retention in Human Bone Tissue by Inductively Coupled Plasma Atomic Emission Spectroscopy
| Autor: | Wendell A. Gibby, W. Andrew Gibby, Krissa A. Gibby |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Gadolinium DTPA
Gadolinium-Chelate business.industry Chemistry Spectrophotometry Atomic Contrast Media Reproducibility of Results Human bone Femur Head Gadolinium General Medicine Middle Aged Gd-DTPA-BMA Sensitivity and Specificity Hip joint replacement Heterocyclic Compounds Inductively coupled plasma atomic emission spectroscopy Organometallic Compounds Humans Radiology Nuclear Medicine and imaging Nuclear medicine business Aged |
| Zdroj: | Investigative Radiology. 39:138-142 |
| ISSN: | 0020-9996 |
| DOI: | 10.1097/01.rli.0000112789.57341.01 |
| Popis: | Human bone tissue was collected following administration of a clinical dose of gadolinium chelate (0.1 mmol per kg) to patients undergoing hip joint replacement surgery to determine if measurable differences in Gd deposition occur between 2 widely available magnetic resonance contrast agents.Gd HP-DO3A (ProHance), Gd DTPA-BMA (Omniscan), and an age-matched control population without history of gadolinium chelate administration were compared. Bone samples were collected fresh, placed in refrigeration, and subsequently frozen. Tissue digestion was performed using a microwave tissue digester and concentrated nitric acid. A method of tissue analysis was created for gadolinium using inductivity coupled plasma atomic emission spectroscopy (ICP-AES).Tissue retention was 1.18 +/- .787 microg Gd/g bone (N = 10) for Omniscan and 0.466 +/- .387 microg Gd/g bone (N = 8) for ProHance measured by ICP-AES.Omniscan (Gd DTPA-BMA) left 2.5 times more Gd behind in bone than did ProHance (Gd HP-DO3A). |
| Databáze: | OpenAIRE |
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