Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells
| Autor: | Imali A. Mudunkotuwa, Angie S. Morris, Vicki H. Grassian, Douglas R. Spitz, Amaraporn Wongrakpanich, Kranti A. Mapuskar, Sean M. Geary, Aliasger K. Salem |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
inorganic chemicals
Copper oxide Materials science Materials Science (miscellaneous) Inorganic chemistry Cell Oxide Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Article chemistry.chemical_compound mental disorders medicine Cytotoxicity Dissolution health care economics and organizations General Environmental Science technology industry and agriculture respiratory system 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure chemistry Cell culture Biophysics 0210 nano-technology Intracellular |
| Zdroj: | Environmental science. Nano. 3(2) |
| ISSN: | 2051-8153 |
| Popis: | The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu2+ and causing a differential impact on cytotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|