Immune Defects in 28-kDa Proteasome Activator γ-Deficient Mice
| Autor: | Satvir S. Tevethia, Lance F. Barton, George S. Deepe, John J. Monaco, Yunjung Cho, Todd D. Schell, Reta S. Gibbons, Herbert A. Runnels |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Proteasome Endopeptidase Complex T cell Histoplasma Immunology Epitopes T-Lymphocyte Mitosis Simian virus 40 CD8-Positive T-Lymphocytes Biology Weight Gain Autoantigens Epitope Mice Mitotic cell cycle Immune system Multienzyme Complexes medicine Animals Immunology and Allergy Lymphocyte Count Antigens Viral Tumor Histoplasmosis Cells Cultured Mice Knockout Antigen Presentation Activator (genetics) Histocompatibility Antigens Class I Immunologic Deficiency Syndromes Nuclear Proteins Molecular biology Cell biology Mice Inbred C57BL Cysteine Endopeptidases medicine.anatomical_structure Proteasome Gene Targeting Mutation Signal transduction Cell Division CD8 |
| Zdroj: | The Journal of Immunology. 172:3948-3954 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.172.6.3948 |
| Popis: | Protein complexes of the 28-kDa proteasome activator (PA28) family activate the proteasome and may alter proteasome cleavage specificity. Initial investigations have demonstrated a role for the IFN-γ-inducible PA28α/β complex in Ag processing. Although the noninducible and predominantly nuclear PA28γ complex has been implicated in affecting proteasome-dependent signaling pathways, such as control of the mitotic cell cycle, there is no previous evidence demonstrating a role for this structure in Ag processing. We therefore generated PA28γ-deficient mice and investigated their immune function. PA28γ−/− mice display a slight reduction in CD8+ T cell numbers and do not effectively clear a pulmonary fungal infection. However, T cell responses in two viral infection models appear normal in both magnitude and the hierarchy of antigenic epitopes recognized. We conclude that PA28γ−/− mice, like PA28α−/−/β−/− mice, are deficient in the processing of only specific Ags. |
| Databáze: | OpenAIRE |
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