A clinical study of amiodarone as a single oral dose in patients with recent-onset atrial tachyarrhythmia
| Autor: | C. Vu Ngoc, Pierre Andrivet, V. Mach, P. J. Dove, E. Boubakri |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Heart disease Population Administration Oral Amiodarone Loading dose Oral administration Tachycardia Internal medicine Atrial Fibrillation Heart rate medicine Humans Sinus rhythm Prospective Studies Infusions Intravenous education Atrial tachycardia Aged education.field_of_study business.industry Middle Aged medicine.disease Atrial Flutter Anesthesia Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies medicine.drug |
| Zdroj: | European Heart Journal. 15:1396-1402 |
| ISSN: | 1522-9645 0195-668X |
| Popis: | Forty-five patients with recent-onset sustained atrial tachyarrhythmia (mean heart rate at entry; 140.0 +/- 3.5 beats.min-1) associated with various cardiovascular diseases were treated by oral amiodarone, given as a single loading dose of 25.7 +/- 0.9 mg.kg-1 body weight. Conversion to sinus rhythm was observed in 29 patients during the first 24 h of treatment, leading to a success rate of 64.4%. Five additional patients converted to sinus rhythm with continuation of oral amiodarone, (10-15 mg.kg-1 by day) with a mean delay of 4.2 days. A similar population of 27 patients (mean heart rate at entry; 140 +/- 3 beats.min-1) was treated by intravenous amiodarone, given as a bolus infusion of 3-5 mg.kg-1 over 30 min (mean; 4.1 +/- 0.2 mg.kg-1), followed by a continuous infusion of 10-15 mg.kg-1 for 24 h (mean; 11.1 +/- 0.7 mg.kg-1). Eighteen patients converted to sinus rhythm during the first 24 h of therapy, leading to a success rate of 66.7%. Minor adverse effects of therapy were observed in two patients given oral amiodarone, and in seven given intravenous amiodarone. No major effect was observed. We suggest that amiodarone given as a single oral loading dose of 25-30 mg.kg-1 body weight is an effective, simple and well-tolerated therapy, suitable for most patients with recent-onset ATA. |
| Databáze: | OpenAIRE |
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