The anti-immobility effect of hyperoside on the forced swimming test in rats is mediated by the D2-like receptors activation
| Autor: | Eveline Dischkaln Stolz, Juliana Schulte Haas, Andresa Heemann Betti, Ana Cristina Stein, Jan Schripsema, Stela Maris Kuze Rates, Gilsane Lino von Poser |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pentobarbital Pharmaceutical Science Hyperoside Mice Inbred Strains Pharmacology Open field Analytical Chemistry chemistry.chemical_compound Mice Drug Discovery medicine Animals Rats Wistar Swimming biology Behavior Animal Depression Plant Extracts Receptors Dopamine D2 Organic Chemistry Hypericum perforatum Central Nervous System Depressants Plant Components Aerial biology.organism_classification Antidepressive Agents Rats Dopamine D2 Receptor Antagonists Complementary and alternative medicine chemistry Toxicity Molecular Medicine Dopamine Antagonists Quercetin Sulpiride Hypericum Sleep Brazil Behavioural despair test medicine.drug Phytotherapy |
| Zdroj: | Planta medica. 77(4) |
| ISSN: | 1439-0221 |
| Popis: | The crude extracts of Hypericum species native to South Brazil showed analgesic and antidepressant-like effects in rodents. The chemical characterization of these species revealed that they are rich in flavonoids and phloroglucinol derivatives. In the present study a detailed investigation was performed on the activities of hyperoside (HYP), a common flavonoid in the genus Hypericum. Hyperoside was obtained from the aerial parts of H. caprifoliatum by chromatographic procedures. Mice treated with single doses (10, 20 and 40 mg/kg i.p.) did not present signs of toxicity or weight loss. At 20 and 40 mg/kg i.p. the mice exploratory behavior in the open field test was reduced. At 20 mg/kg i. p. the pentobarbital sleeping time increased, but not the sleeping latency. No activity was found on the hot-plate (10 and 20 mg/kg i.p.) or in the acetic acid-induced writhing test (20 and 40 mg/kg p.o.). Nevertheless, an antidepressant-like effect in the forced swimming test in mice and rats was observed (HYP 10 and 20 mg/kg i.p. in mice; HYP 1.8 mg/kg/day p.o. in rats). The antidepressant-like effect in rats was prevented by the administration of sulpiride (50 mg/kg i.p.) a D2 antagonist. In conclusion, hyperoside was found to present a depressor effect on the central nervous system as well as an antidepressant-like effect in rodents which is, at least in part, mediated by the dopaminergic system. |
| Databáze: | OpenAIRE |
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