Stressors increase leptin receptor-expressing thymic epithelial cells in the infant/child thymus
| Autor: | Takashi Saito, Koichi Suzuki, Takako Sato, Shuntaro Abe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Child abuse medicine.medical_specialty Thymus Gland Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Stress Physiological Internal medicine medicine Humans Involution (medicine) Child Forensic Pathology Thymic involution Leptin receptor business.industry Leptin Stressor Infant Newborn Infant Epithelial Cells 030104 developmental biology Endocrinology Case-Control Studies Child Preschool Receptors Leptin Female Forensic autopsy business Biomarkers Immunostaining 030215 immunology |
| Zdroj: | International Journal of Legal Medicine. 132:1665-1670 |
| ISSN: | 1437-1596 0937-9827 |
| DOI: | 10.1007/s00414-018-1793-9 |
| Popis: | The thymus, the organ that is the most sensitive to stress, presents acute involution as a result of exposure to strong stress in childhood. Thymic involution is thus often considered evidence of child abuse/neglect in forensic autopsies. A portion of the thymic epithelial cells express leptin receptor, and leptin showed a thymo-protective function against stress-induced thymic involution in an animal model. Leptin receptor-expressing thymic epithelial cells (LR-TECs) may play a key role in the thymic remodeling provoked by a stressful environment. Here, we sought to clarify the changes of histopathological findings and human LR-TECs in stressful environment. We examined human thymus specimens obtained from 40 forensic autopsy cases (26 male, 14 female; age 21 to 3221 days). We divided the cases into stressor-positive (SP, n = 29) and stressor-negative (SN, n = 11) groups. Cases were classified according to the histological classification of thymic involution and investigated by leptin receptor immunostaining. The results revealed that (1) the SP group showed obvious histological thymic involution (p |
| Databáze: | OpenAIRE |
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