Relationship between structural abnormalities and short-wavelength perimetric defects in eyes at risk of glaucoma
Autor: | Seyda Ugurlu, Joseph Caprioli, Douglas Hoffman, David F Garway-Heath |
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Rok vydání: | 2000 |
Předmět: |
Retinal Ganglion Cells
medicine.medical_specialty genetic structures Open angle glaucoma Optic Disk Nerve fiber layer Optic disk Ocular hypertension Glaucoma Ophthalmoscopy Nerve Fibers Risk Factors Ophthalmology medicine Photography Humans Prospective Studies Tomography Observer Variation medicine.diagnostic_test business.industry Optic Nerve Middle Aged medicine.disease eye diseases medicine.anatomical_structure Optic nerve Visual Field Tests Ocular Hypertension sense organs Abnormality Visual Fields business Glaucoma Open-Angle |
Zdroj: | American journal of ophthalmology. 129(5) |
ISSN: | 0002-9394 |
Popis: | PURPOSE: To determine the relative prevalence of blue-yellow perimetric defects and structural abnormalities of the optic nerve and nerve fiber layer in eyes at risk of glaucoma. METHODS: Seventy-two eyes (of 72 patients) at risk of glaucoma, with normal white-on-white full threshold perimetry, were examined prospectively with blue-yellow full-threshold perimetry (Humphrey). Structural evaluations were conducted with qualitative assessment of stereoscopic color optic disk photographs and monochromatic nerve fiber layer photographs performed independently by three masked examiners (a glaucoma specialist and two glaucoma fellows), and statistical analysis of summary parameters was obtained with scanning confocal laser tomography (abnormal defined as values outside 95% confidence limits established in normal control subjects). RESULTS: Kappa values for interobserver agreement were 0.64, 0.88, and 0.79 for optic disk evaluation and 0.59, 0.60, and 0.61 for nerve fiber layer evaluation. Thirteen (18%) of 72 eyes had blue-yellow abnormalities. A total of 30 eyes (42%) were identified as having a structural abnormality; 29 (40%) had qualitatively determined optic disk abnormalities, 21 (29%) had qualitatively determined nerve fiber layer defects, and 26 (36%) had statistically significant structural abnormalities. Twelve of 13 eyes with blue-yellow defects had a detectable structural abnormality; all 12 had abnormalities identified with disk photography, nine with nerve fiber layer photography, and 12 by scanning laser tomography. CONCLUSIONS: Clinically detectable structural abnormalities frequently coexist with blue-yellow perimetric defects in patients with ocular hypertension. A substantial proportion of patients with ocular hypertension with normal blue-yellow perimetry has early detectable glaucomatous structural abnormalities. |
Databáze: | OpenAIRE |
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