Synthesis of pH- and thermoresponsive poly(2-n -propyl-2-oxazoline) based copolymers
| Autor: | Marcel A. Boerman, Harry L. van der Laan, Johan C. M. E. Bender, Richard Hoogenboom, Sander C.G. Leeuwenburgh, John A. Jansen, Jan C. M. van Hest |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Polymers and Plastics Chemistry Carboxylic acid Organic Chemistry Cationic polymerization 02 engineering and technology Oxazoline Polymer 010402 general chemistry 021001 nanoscience & nanotechnology Bio-Organic Chemistry 01 natural sciences Lower critical solution temperature Ring-opening polymerization 0104 chemical sciences chemistry.chemical_compound Polymer chemistry Materials Chemistry Side chain Copolymer 0210 nano-technology |
| Zdroj: | Journal of Polymer Science Part A-Polymer Chemistry, 54, 11, pp. 1573-1582 Journal of Polymer Science Part A-Polymer Chemistry, 54, 1573-1582 |
| ISSN: | 0887-624X |
| DOI: | 10.1002/pola.28011 |
| Popis: | Polymers that possess lower critical solution temperature behavior such as poly(2-alkyl-2-oxazoline)s (PAOx) are interesting for their application as stimulus-responsive materials, for example in the biomedical field. In this work, we discuss the scalable and controlled synthesis of a library of pH- and temperature-sensitive 2-n-propyl-2-oxazoline P(nPropOx) based copolymers containing amine and carboxylic acid functionalized side chains by cationic ring opening polymerization and postpolymerization functionalization strategies. Using turbidimetry, we found that the cloud point temperature (CP) is strongly dependent on both the polymer concentration and the polymer charge (as a function of pH). Furthermore, we observed that the CP decreased with increasing salt concentration, whereas the CP increased linearly with increasing amount of carboxylic acid groups. Finally, turbidimetry studies in PBS-buffer indicate that CPs of these polymers are close to body temperature at biologically relevant polymer concentrations, which demonstrates the potential of P(nPropOx) as stimulus-responsive polymeric systems in, for example, drug delivery applications. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 |
| Databáze: | OpenAIRE |
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