Klebsiella pneumoniae and Klebsiella oxytoca meningitis in infants. Epidemiological and clinical features

Autor: Laurence Caeymaex, C. Charreton, O. Zafer, Joël Gaudelus, L. de Pontual, Robert Cohen, J. Baleine, B. Coche-Monier, F. Lageix, C. Alexandre, Violaine Walewski, Corinne Levy, E. Carbonnelle, Mathie Lorrot, Didier Pinquier, S. Klosowski, L. Hess, C. Carrie
Přispěvatelé: Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Sorbonne Paris Nord, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier d'Aix en Provence [Aix-en-Provence] (CHIAP ), Hôpital Simone Veil [Eaubonne], Centre Hospitalier Intercommunal de Créteil (CHIC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier de Lens, Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Groupe Hospitalier Public du Sud de l'Oise [Creil] (GHPSO), Groupe Hospitalier Hôpitaux Universitaires Paris Seine-Saint-Denis [Bobigny] (GH HUPSSD), Hôpital Jean Verdier [AP-HP], CHU Rouen, Normandie Université (NU), Université Paris-Est (UPE), CCSD, Accord Elsevier, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10
Rok vydání: 2018
Předmět:
Zdroj: Archives de Pédiatrie
Archives de Pédiatrie, 2019, 26 (1), pp.12-15. ⟨10.1016/j.arcped.2018.09.013⟩
Archives de Pédiatrie, Elsevier, 2019, 26 (1), pp.12-15. ⟨10.1016/j.arcped.2018.09.013⟩
ISSN: 1769-664X
0929-693X
DOI: 10.1016/j.arcped.2018.09.013⟩
Popis: International audience; Background: The incidence of meningitis caused by Klebsiella pneumoniae (Kp) and Klebsiella oxytoca (Ko) in high-income countries is unknown, and no series have been published to date.Methods: We conducted a nationwide multicenter observational study in France between 2006 and 2016. All children from the French national registry for paediatric bacterial meningitis under the age of 1 year and hospitalized for Kp or Ko meningitis were included. Virulence factors of four Klebsiella spp. strains were explored by whole genome sequencing.Results: Of 1859 cases of meningitis in children under the age of 1 year, 13 cases (0.7%) of Klebsiella spp. meningitis (nine for Kp meningitis and four for Ko meningitis) were registered in the French national registry. Three of the patients died and 50% of the survivors had developmental delays.Conclusions: Prematurity, low birth weight, and congenital anomalies of the urinary tract appear to be risk factors for Klebsiella spp. meningitis as well as virulence factors of the strain.
Databáze: OpenAIRE
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