Eradication of carriage with methicillin-resistant Staphylococcus aureus: effectiveness of a national guideline
| Autor: | Ammerlaan, H.S.M., Kluytmans, J.A.J.W., Berkhout, H., Buiting, A., Brauwer, E.I.G.B. de, Broek, P.J. van den, Gelderen, P. van, Leenders, S.C.A.P., Ott, A., Richter, C., Spanjaard, L., Spijkerman, I.J.B., Tiel, F.H. van, Voorn, G.P., Wulf, M.W.H., Zeijl, J. van, Troelstra, A., Bonten, M.J.M., MRSA Eradication Study Grp |
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| Přispěvatelé: | Medical Microbiology and Infection Prevention, CCA - Immuno-pathogenesis, AII - Amsterdam institute for Infection and Immunity, Med Microbiol, Infect Dis & Infect Prev, RS: CAPHRI School for Public Health and Primary Care |
| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
Pediatrics medicine.medical_specialty Mupirocin medicine.disease_cause Staphylococcal infections chemistry.chemical_compound Interquartile range medicine Pharmacology (medical) Prospective cohort study success Pharmacology treatment business.industry Dutch guideline Guideline colonization medicine.disease Methicillin-resistant Staphylococcus aureus Infectious Diseases Carriage chemistry colonization treatment decolonization success Dutch guideline nosocomial infections intranasal mupirocin hospital admission nasal carriers risk-factors colonization duration mrsa prevalence decolonization business Cohort study |
| Zdroj: | Journal of Antimicrobial Chemotherapy, 66(10), 2409-2417. Oxford University Press Journal of Antimicrobial Chemotherapy, 66(10), 2409-2417 Journal of antimicrobial chemotherapy, 66(10), 2409-2417. Oxford University Press Ammerlaan, H S M, Kluijtmans, J A J W, Berkhout, H, Buiting, A, de Brauwer, E I G B, van den Broek, P J, van Gelderen, P, Leenders, S C A P, Ott, A, Richter, C, Spanjaard, L, Spijkerman, I J B, van Tiel, F H, Voorn, G P, Wulf, M W H, van Zeijl, J, Troelstra, A & Bonten, M J M 2011, ' Eradication of carriage with methicillin-resistant Staphylococcus aureus: effectiveness of a national guideline ', Journal of Antimicrobial Chemotherapy, vol. 66, no. 10, pp. 2409-2417 . https://doi.org/10.1093/jac/dkr243 |
| ISSN: | 0305-7453 |
| Popis: | Background: We evaluated the effectiveness of eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage in the Netherlands after the introduction of a guideline in 2006. The guideline distinguishes complicated (defined as the presence of MRSA infection, skin lesions, foreign-body material, mupirocin resistance and/or exclusive extranasal carriage) and uncomplicated carriage (not meeting criteria for complicated carriage). Mupirocin nasal ointment and chlorhexidine soap solution are recommended for uncomplicated carriers and the same treatment in combination with two oral antibiotics for complicated carriage. Methods: A prospective cohort study was performed in 18 Dutch centres from 1 October 2006 until 1 October 2008. Results: Six hundred and thirteen MRSA carriers underwent one or more decolonization treatments during the study period, mostly after hospital discharge. Decolonization was achieved in 367 (60%) patients with one eradication attempt and ultimately 493 (80%) patients were decolonized, with a median time until decolonization of 10 days (interquartile range 7-43 days). Three hundred and twenty-seven (62%) carriers were treated according to the guideline, which was associated with an absolute increase in treatment success of 20% [from 45% (91/203) to 65% (214/327)]. Conclusions: Sixty percent of MRSA carriers were successfully decolonized after the first eradication attempt and 62% were treated according to the guideline, which was associated with an increased treatment success. |
| Databáze: | OpenAIRE |
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