The Role of Iodine in the Pathogenesis of Thyroid Enlargement in Rats with Chronic Renal Failure
| Autor: | Brent F. Robertson, William Jubiz, William M. O'Neill, German Ramirez, Sandra Prestwich |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Wolff–Chaikoff effect Goiter medicine.medical_treatment Thyroid Gland Thyrotropin chemistry.chemical_element Iodine Nephrectomy Blood Urea Nitrogen Pathogenesis Endocrinology Internal medicine Animals Medicine Ingestion Blood urea nitrogen business.industry Thyroid Organ Size medicine.disease Diet Rats Thyroxine medicine.anatomical_structure chemistry Kidney Failure Chronic Triiodothyronine business |
| Zdroj: | Endocrinology. 101:1272-1275 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-101-4-1272 |
| Popis: | In rats with mild renal failure produced by a 2/3 nephrectomy on one side followed by a total nephrectomy on the other, ingestion of a high (10 mg/kg) iodine diet for two months resulted in thyromegaly, high serum iodine levels and a good correlation between thyroid weight and serum iodine (r = 0.75, P less than 0.01) or thyroid weight and blood urea nitrogen (r = 0.745, P less than 0.01). Iodine may potentiate the effects of unidentified gointrogens that accumulate in rats with renal failure. Since the serum iodine levels were higher in the animals with renal failure, it is also possible that iodine alone may have been responsible for the observed differences in thyroid weight. |
| Databáze: | OpenAIRE |
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