Reduced C0 Concentrations and Increased Dose Requirements in Renal Allograft Recipients Converted to the Novel Once-Daily Tacrolimus Formulation
| Autor: | Dirk Kuypers, Kristin Verbeke, Hylke de Jonge, Yves Vanrenterghem |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Renal function Pharmacology Drug Administration Schedule Tacrolimus Dosage form chemistry.chemical_compound Pharmacokinetics medicine Cytochrome P-450 CYP3A Humans Transplantation Homologous Aged Retrospective Studies Antibacterial agent Transplantation Creatinine Dose-Response Relationship Drug business.industry DNA Middle Aged Kidney Transplantation Calcineurin Dose–response relationship chemistry Female business Immunosuppressive Agents Glomerular Filtration Rate |
| Zdroj: | Transplantation. 90:523-529 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0b013e3181e9feda |
| Popis: | Background. Recently, a once-daily prolonged release formulation of tacrolimus (TacOD) has been approved for the prevention of renal allograft rejection. Studies reported equivalent area under the concentration-time curve 0-24 and predose trough (C 0 ) concentrations when compared with the standard twice-daily tacrolimus (Tac) formulation. Hence, the package insert advices a 1:1 mg conversion. Here, we report our independent experience with conversion to TacOD according to the manufacturer's instructions. Methods. Retrospective single-center study evaluating the evolution of C 0 concentrations and dose requirements after conversion to TacOD in 284 renal allograft recipients. Potential clinical, biochemical, and genetic determinants of changes in C 0 concentrations and dose requirements after conversion were explored in univariate and multivariate analyses. Results. After conversion, C 0 concentrations decreased significantly (-1.36±2.51 μg/L or -12.66%±24.36%, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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