Continuum of phenotypes and sympathoadrenal function in premature adrenarche
| Autor: | Raimo Voutilainen, Pauliina Utriainen, Jarmo Jääskeläinen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System medicine.drug_class Endocrinology Diabetes and Metabolism Adrenal Gland Diseases Dehydroepiandrosterone Pubarche chemistry.chemical_compound Catecholamines Endocrinology Dehydroepiandrosterone sulfate Adrenal Cortex Hormones Internal medicine Adrenal Glands Humans Medicine Congenital adrenal hyperplasia Androstenedione Child Adrenal Hyperplasia Congenital business.industry Adrenarche General Medicine Androgen medicine.disease Phenotype chemistry Data Interpretation Statistical Androgens Catecholamine Female Steroids business Gonadotropins medicine.drug |
| Zdroj: | European Journal of Endocrinology. 160:657-665 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ObjectivesPremature adrenarche (PA), the early rise in adrenal androgen (AA) production, can manifest with different clinical signs of androgen effect. Premature pubarche defined as appearance of pubic hair before the age of 8/9 years in girls/boys, is the most prominent clinical sign of PA and often erroneously described as a synonym of PA. Our aim was to determine the association of circulating AA concentrations with different prepubertal signs of androgen action (SAA). Secondly, we tested whether adrenomedullary function is altered in children with SAA, as it is in congenital adrenal hyperplasia (CAH) also causing adrenal hyperandrogenism.Design and methodsWe examined 73 Finnish prepubertal children with any hyperandrogenic sign(s) having appeared before the age of 8/9 years (girls/boys) (35 with pubic and/or axillary hair=PAH; 38 without=nonPAH), and 98 age- and sex-matched controls. Circulating adrenal steroid and catecholamine concentrations were measured and correlated with clinical parameters.ResultsNone of the children with SAA had CAH or virilizing tumor. Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione concentrations overlapped between the SAA and control children, and they were lower in the nonPAH than PAH group (PP=0.03).ConclusionsPA forms a continuum with more pronounced increase in circulating androgens in children with PAH than in those without. Some children show SAA with fairly low androgen concentrations. The clinical significance of elevated NE concentrations associated with SAA needs to be confirmed in further studies. |
| Databáze: | OpenAIRE |
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