Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age

Autor: Joan O. Grimalt, Jordi Julvez, Jordi Sunyer, Daniel Carrizo, Núria Ribas-Fitó, Maties Torrent
Jazyk: angličtina
Rok vydání: 2007
Předmět:
embarazo
intercambio materno-fetal
Health
Toxicology and Mutagenesis
humanos
prenatal exposure
Social competence
trastornos de déficit de atención con hiperactividad
contaminantes atmosféricos
estudios de seguimiento
Toxicology
chemistry.chemical_compound
CORD SERUM
Pregnancy
Prenatal exposure
Hexachlorobenzene
HCB
Children
Maternal-Fetal Exchange
cord serum
Psychomotor learning
Air Pollutants
social competence
adulto
Fetal Blood
Maternal Exposure
Child
Preschool
Prenatal Exposure Delayed Effects
Children's Health
Epidemiological Monitoring
Female
Hexachlorobenzene (HCB)
efectos diferidos por exposición prenatal
Environmental Monitoring
Adult
sangre fetal
monitorización epidemiológica
conducta social
children
medicine
Humans
Behaviour
Social Behavior
business.industry
behavior
Research
Public Health
Environmental and Occupational Health
Cord serum
medicine.disease
Confidence interval
Hyperactivity
hyperactivity
chemistry
Spain
Attention Deficit Disorder with Hyperactivity
Relative risk
hexaclorobenceno
business
Demography
Follow-Up Studies
monitorización del ambiente
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
Environmental Health Perspectives
Popis: 4 pages, 4 tables.-- PMID: 17431497 [PubMed].-- PMCID: PMC1849941.
[Background] Hexachlorobenzene (HCB) is an organochlorine chemical that has been used in agriculture and industrial processes. Behavioral impairment after HCB exposure has been described in animal models, but little information is available in humans.
[Objectives] Our goal was to study the association of prenatal exposure to HCB with the social behavior of preschool children.
[Methods] Two birth cohorts in Ribera d’Ebre and Menorca (Spain) were set up between 1997 and 1999 (n = 475). The California Preschool Social Competence Scale and the Attention-Deficit Hyperactivity Disorder (ADHD) were scored by each 4-year-old child’s teacher. Organochlorine compounds were measured in cord serum. Children’s diet and parental sociodemographic information were obtained through questionnaire.
[Results] Children with concentrations of HCB > 1.5 ng/mL at birth had a statistically significant increased risk of having poor Social Competence [relative risk (RR) = 4.04; 95% confidence interval (CI), 1.76–9.58] and ADHD (RR = 2.71; 95% CI, 1.05–6.96) scores. No association was found between HCB and the cognitive and psychomotor performance of these children.
[Conclusions] Prenatal exposure to current concentrations of HCB in Spain is associated with a decrease in the behavioral competence at preschool ages. These results should be considered when evaluating the potential neurotoxicologic effects of HCB.
This study was funded by grants from the Spanish Ministry of Health (FIS-97/1102, FIS-PI041436), Instituto de Salud Carlos III (Red RCESP C03/09 and Red INMA G03/176), Fundació “la Caixa” (97/009-00 and 00/077-00), and the Generalitat de Catalunya-CIRIT (1999SGR 00241).
Databáze: OpenAIRE
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