Steroid withdrawal at 3 months after kidney transplantation: a comparison of two tacrolimus-based regimens
| Autor: | Petr Bachleda, Karoly Nagy Kalmar, Marek Ostrowski, Ferenc Perner, Pavel Navrátil, Pavel Studenik, Franciszek Kokot, Pál Szenohradszky, Stefan Vitko, J Wałaszewski, László Asztalos, David P. Hickey, Marian Klinger, Zbigniew Wlodarczyk, Bolesław Rutkowski |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent Prednisolone Urology Renal function chemical and pharmacologic phenomena Azathioprine Methylprednisolone Mycophenolic acid Tacrolimus chemistry.chemical_compound stomatognathic system medicine Humans Prospective Studies Kidney transplantation Antibacterial agent Aged Transplantation Creatinine business.industry Middle Aged Mycophenolic Acid medicine.disease Kidney Transplantation Surgery stomatognathic diseases chemistry Female Steroids business Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplant international : official journal of the European Society for Organ Transplantation. 18(2) |
| ISSN: | 0934-0874 |
| Popis: | The 6 month prospective, randomized study compared the steroid-sparing potential of two tacrolimus-based regimens after renal transplantation. A total of 489 patients were randomized (1:1) to receive tacrolimus/mycophenolate mofetil (MMF)/steroids (n = 243; group Tac/MMF/S) or tacrolimus/azathioprine/steroids (n = 246; group Tac/Aza/S). At 3 months, steroids were tapered off in 267 (54.6%) patients free from steroid-resistant acute rejection and with serum creatinine concentrations |
| Databáze: | OpenAIRE |
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