Acute and sub-chronic 90-day oral toxicity study of Perilla seed oil in rodents and Beagle dogs
| Autor: | Jian Guan, Hui-xing Zhang, Yuqing Zhao, Yi-hong Tian, Guang-yue Su |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty No-observed-adverse-effect level Dose Physiology Administration Oral Mice Inbred Strains 010501 environmental sciences Toxicology 030226 pharmacology & pharmacy 01 natural sciences Beagle 03 medical and health sciences Mice 0302 clinical medicine Dogs Oral administration medicine Animals Plant Oils Rats Wistar 0105 earth and related environmental sciences biology Dose-Response Relationship Drug business.industry Toxicity Tests Subchronic alpha-Linolenic Acid General Medicine Perilla biology.organism_classification Acute toxicity Rats Liver Toxicity Histopathology Female Lymph Nodes business |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 103 |
| ISSN: | 1096-0295 |
| Popis: | Perilla seeds are used as food and traditional medicine in China. This study aimed to investigate the toxicity profile of Perilla seed oil (PSO), which is the main constituent of Perilla seeds in rodents and Beagle dogs. No significant treatment-associated toxicity or mortality was observed at PSO dosages of up to 50 g/kg and 20 g/kg in KM mice and Wistar rats, respectively, suggesting that PSO was well tolerated by the experimental rodents. Sub-chronic oral toxicity of PSO was studied in dogs at doses of 3, 6 and 12 g/kg/d for 90 days followed by a 30 day recovery period. The results indicated that the body weight increased in all-dose groups more than control group, typical of animals on diets rich in fatty acids. Treatment-related side effects, including changes in hematology and serum biochemistry parameters, histopathology of liver and lymph glands, were observed in the high and moderate-dose dogs. However, these changes disappeared after the doses were withdrawn during the recovery period, except for alteration of liver in the high-dose group. In conclusion, the “no observed adverse effect level” (NOAEL) of oral administration of PSO for 90 days in Beagle dogs was considered to be 3 g/kg/d. |
| Databáze: | OpenAIRE |
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