Female rats are more susceptible to metabolic effects of dehydroepiandrosterone treatment
| Autor: | Ana Lúcia Cecconello, Ana Lúcia Hoefel, Aline Gonçalves Cozer, Claudia Vieira-Marques, Maria Flavia Marques Ribeiro, Luiz Carlos Rios Kucharski, Bruno Dutra Arbo |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Physiology Glucose uptake medicine.medical_treatment Adipose tissue Dehydroepiandrosterone White adipose tissue Carbohydrate metabolism 03 medical and health sciences 0302 clinical medicine Sex Factors Physiology (medical) Internal medicine polycyclic compounds medicine Animals Rats Wistar Muscle Skeletal Pharmacology business.industry Lipogenesis Body Weight General Medicine Metabolism Lipids Rats Steroid hormone 030104 developmental biology Endocrinology Glucose Adipose Tissue Liver Metabolic effects Models Animal Female business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Glycogen |
| Zdroj: | Canadian journal of physiology and pharmacology. 96(11) |
| ISSN: | 1205-7541 |
| Popis: | Dehydroepiandrosterone (DHEA) is a steroid hormone that presents several effects on metabolism; however, most of the studies have been performed on male animals, while few authors have investigated possible sex differences regarding the metabolic effects of DHEA. Therefore, the aim of this study was to evaluate the effect of different doses of DHEA on metabolic parameters of male and ovariectomized female Wistar rats. Sex differences were found in the metabolism of distinct substrates and in relation to the effect of DHEA. In respect to the glucose metabolism in the liver, the conversion of glucose to CO2 and the synthesis of lipids from glucose were 53% and 33% higher, respectively, in males. Also, DHEA decreased hepatic lipogenesis only in females. Regarding the hepatic glycogen synthesis pathway, females presented 73% higher synthesis than males, and the effect of DHEA was observed only in females, where it decreased this parameter. In the adipose tissue, glucose uptake was 208% higher in females and D... |
| Databáze: | OpenAIRE |
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