DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators
| Autor: | Dimitrios Athanasiadis, Anna Sioziou, Christos Klonaris, Evangelia Legaki, Theodoros Liakakos, Maria Gazouli, Nikolaos Patelis |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Mrna expression Gene Expression macromolecular substances Comorbidity General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Medicine Humans Enhancer of Zeste Homolog 2 Protein Differential expression Gene Aged Pharmacology Aged 80 and over Transition (genetics) business.industry Cell growth EZH2 medicine.disease Abdominal aortic aneurysm MicroRNAs Gene Expression Regulation Apoptosis ras GTPase-Activating Proteins 030220 oncology & carcinogenesis cardiovascular system Female RNA Interference business Biomarkers Aortic Aneurysm Abdominal Research Article |
| Zdroj: | In vivo (Athens, Greece). 33(3) |
| ISSN: | 1791-7549 |
| Popis: | Background/aim Nine genetic loci have been associated with abdominal aortic aneurysm (AAA) susceptibility, including DAB2IP. This gene is playing a role in apoptosis, cell proliferation and epithelial-to-mesenchymal transition in cancers. This study aimed to elucidate the differential expression levels of DAB2IP in AAA tissues and investigate whether mir-363-3p and EZH2 can be considered as potential mediators of its expression. Materials and methods 18 AAA samples and 15 non-aneurysmatic controls were collected. Relative mRNA expression levels of DAB2IP, EZH2 and mir-363-3p were measured using qPCR. Results DAB2IP was significant up-regulated (~2.29 fold) in AAA tissues, while EZH2 and mir-363-3p were down-regulated (3.28 and 3.62-fold, respectively). A limited negative correlation was found between the DAB2IP and EZH2 expression and between DAB2IP and the mir-363-3p. Conclusion An increased expression of DAB2IP in AAA tissues was shown. We suggest 2 potential mediators of DAB2IP expression in abdominal aortic aneurysm, EZH2 and mir-363-3p. |
| Databáze: | OpenAIRE |
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