Cancer in adolescents and young adults (15–29 years): A population-based study in the Netherlands 1989–2009

Autor: Gerhard A. Zielhuis, Katja K.H. Aben, Nienke A van Gils, Winette T. A. van der Graaf, J. Carlijn van Gaal
Rok vydání: 2012
Předmět:
Adult
Male
Risk
Pediatrics
medicine.medical_specialty
Skin Neoplasms
Adolescent
Population
Breast Neoplasms
Young Adult
Age Distribution
Testicular Neoplasms
Quality of life
Translational research [ONCOL 3]
Evaluation of complex medical interventions Aetiology
screening and detection [NCEBP 2]
Neoplasms
medicine
Humans
Radiology
Nuclear Medicine and imaging
Sex Distribution
Young adult
education
Human Reproduction Aetiology
screening and detection [NCEBP 12]
Melanoma
Survival rate
Molecular epidemiology Aetiology
screening and detection [NCEBP 1]
Netherlands
education.field_of_study
Relative survival
business.industry
Incidence
Incidence (epidemiology)
Cancer
Age-related aspects of cancer Quality of hospital and integrated care [ONCOL 2]
Neoplasms
Second Primary
Hematology
General Medicine
medicine.disease
Hodgkin Disease
humanities
Cancer registry
Survival Rate
Oncology
Quality of Life
Female
business
Zdroj: Acta Oncologica, 51, 922-33
Acta Oncologica, 51, 7, pp. 922-33
ISSN: 1651-226X
0284-186X
DOI: 10.3109/0284186x.2012.705891
Popis: Item does not contain fulltext Abstract Background. Cancer among adolescents and young adults (AYAs; 15-29 years old) is relatively rare but its incidence is increasing worldwide. To define the extent and nature of the AYA patients, this population-based study was performed to explore trends in cancer incidence, survival and risk of second primary cancers in AYAs. Material and methods. Data from all AYAs diagnosed with cancer between 1989 and 2009 were obtained from the Netherlands Cancer Registry. Age-standardized incidence rates with estimated annual percentage of change (EAPC) and five-year relative survival rates were calculated. Relative survival was used as a good approximation of cause-specific survival. All analyses were stratified by gender, five-year age group and calendar period. In addition, Standardized Incidence Ratios were determined to evaluate the risk of second primary cancers. Results. 23 161 AYAs were diagnosed with cancer between 1989 and 2009. Since 1989 the cancer incidence has increased significantly from 28 to 43 per 100 000 person years in males (EAPC: 1.9) and from 30 to 40 per 100 000 person years in females (EAPC: 1.4). The most frequently diagnosed cancers in male AYAs included testicular cancer, melanoma and Hodgkin's disease, whereas in females melanoma, breast cancer and Hodgkin's disease were the most frequently occurring cancers. Five-year relative survival rates were 80% and 82% for males and females, respectively. Over time, the five-year relative survival increased from 74% to 86% and from 79% to 86% in males and females, respectively. The risk of developing a second primary cancer was increased three to six times in males and two to five times in females, depending on rules for counting second primary cancers. Conclusions. Although the overall survival has improved over time, the progress made in AYAs for specific cancers is still less compared to improvements made in children and adults. This and the increasing incidence and high risk of second primary cancers warrants further research.
Databáze: OpenAIRE
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