Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism
| Autor: | Xianjing Song, Wei Sun, Bin Liu, Yiran Wang, Yinuo Guan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging Angiogenesis Apoptosis Review Article Disease 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation microRNA Gene expression medicine Humans lcsh:QH573-671 Hypoxia Cell Proliferation Regulation of gene expression lcsh:Cytology business.industry Cell Biology General Medicine Hypoxia (medical) MicroRNAs 030104 developmental biology Gene Expression Regulation Cardiovascular Diseases Cancer research medicine.symptom business |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Cardiovascular diseases have high morbidity and mortality rates worldwide, and their treatment and prevention are challenging. MicroRNAs are a series of noncoding RNAs with highly conserved sequences and regulate gene expression by inhibiting mRNA transcription or degrading targeting proteins. MicroRNA-210 is significantly upregulated during hypoxia and plays a protective role by inhibiting apoptosis and regulating cell proliferation, differentiation, migration, mitochondrial metabolism, and angiogenesis in hypoxic cells. MicroRNA-210 expression is altered in cardiovascular diseases such as atherosclerosis, acute myocardial infarction, preeclampsia, aortic stenosis, and heart failure, and overexpression of microRNA-210 in some of these diseases exerts protective effects on target organs. Furthermore, chronically upregulated miR-210 potentially plays a marked pathogenic role in specific situations. This review primarily focuses on the upstream pathways, downstream targets, clinical progress in cardiovascular disease, and potential applications of microRNA-210. |
| Databáze: | OpenAIRE |
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