NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression

Autor:	Andrew Dikman, Jay Desai, Kenneth M. Miller, Andrew Brooks, Masayuki Fukata, Maria T. Abreu, Shefali Sanyal, Tyralee Goo, Qi Wang, James Aisenberg, Lawrence B. Cohen
Rok vydání:	2009
Předmět:	Male medicine.medical_specialty Peptic Ulcer Expression Signature Gene Expression Gastroenterology Article Naproxen Internal medicine Gene expression Gastric mucosa Medicine Humans Pharmacology (medical) Antrum Gene Aged Hepatology business.industry Anti-Inflammatory Agents Non-Steroidal Middle Aged medicine.disease digestive system diseases medicine.anatomical_structure Gastric Mucosa Peptic ulcer Female business
Zdroj:	Alimentary pharmacologytherapeutics. 30(1)
ISSN:	1365-2036
Popis:	The basis for individual variation in gastroduodenal vulnerability to NSAIDs is not well understood.To assess whether a gene expression signature is associated with susceptibility to gastroduodenal ulcerations.Twenty-five Helicobacter pylori negative adults were treated for 7 days with naproxen 500 mg b.d. Subjects underwent baseline and post-treatment endoscopy, during which biopsies were taken from antrum and duodenum. RNA extraction and cDNA synthesis were performed, followed by PCR of 23 genes relevant to mucosal injury and repair. Fold changes in gene expression were compared between subjects who developed ulcers and those who did not.Compared with subjects who did not develop ulcers (n = 18), subjects who developed antral ulcers (n = 7) had significantly greater mucosal up-regulation of interleukin-8 [Fold change = 33.5 (S.E.M. = 18.5) vs. -7.7 (3.2)] and of cyclo-oxygenase-2 [2.3 (1.7) vs. -10.8 (2.2)]. Conversely, non-ulcer subjects had significantly greater up-regulation of toll-like receptor-4, cyclo-oxygenase-1 and hepatocyte growth factor [14.0 (2.2) vs. -0.8 (1.0), 9.8 (2.4) vs. 0.0 (0.7) and 8.2 (2.6) vs. -2.2 (0.3) respectively].NSAID-induced antral ulcers are associated with a specific pattern of gastroduodenal mucosal gene expression. These patterns may provide an insight into the molecular basis of individual susceptibility to mucosal injury.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90c8565380ca25c8b2e7680eeddfcfd https://pubmed.ncbi.nlm.nih.gov/19309390 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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