Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB
| Autor: | Naga Venkatesha Murthy, Rainer Hinz, Sudhakar Selvaraj, Zubin Bhagwagar, Subrata K. Bose, Paul M. Grasby, Philip J. Cowen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Thalamus Central nervous system Sulfides DASB chemistry.chemical_compound Internal medicine mental disorders medicine Humans Depression (differential diagnoses) Serotonin transporter Anterior cingulate cortex Pharmacology Serotonin Plasma Membrane Transport Proteins Depressive Disorder Major Aniline Compounds medicine.diagnostic_test biology Putamen Brain Middle Aged Prognosis medicine.anatomical_structure Endocrinology chemistry nervous system Positron emission tomography Case-Control Studies Positron-Emission Tomography biology.protein Psychology Neuroscience Protein Binding |
| DOI: | 10.1007/s00213-009-1660-y |
| Popis: | BACKGROUND: The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no difference in brain 5-HTT binding between unmedicated recovered depressed patients and healthy controls. AIM: This study aims to assess brain 5-HTT binding in a group of unmedicated acutely depressed patients in comparison to healthy controls. METHODS: We studied 5-HTT binding using [(11)C]DASB in conjunction with positron emission tomography in 12 medication-free depressed patients with a mean duration of illness of about 1 year and 24 healthy controls. RESULTS: The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. CONCLUSIONS: These results suggest that diminished availability of the 5-HTT in the brain may be a state marker of acute depression. Alternatively, low 5-HTT binding may delineate a group of depressed patients with a poor long-term prognosis. |
| Databáze: | OpenAIRE |
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