Pharmacological Management of Atrial Fibrillation: One, None, One Hundred Thousand
| Autor: | Carmelo Massimiliano Rao, Benedetto Daniela, Ludovico Vasquez, Sandro Gelsomino, Fabiana Lucà, Rocco Carella, Roberto Lorusso, Mark La Meir, Orlando Parise, Gian Franco Gensini, Jos G. Maessen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Proarrhythmia
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty business.industry Pharmacological management Atrial fibrillation Review Article medicine.disease Pharmacotherapy Drug development lcsh:RC666-701 Stroke prevention Medicine Sinus rhythm Anticoagulant Agent cardiovascular diseases Cardiology and Cardiovascular Medicine business Intensive care medicine |
| Zdroj: | Cardiology Research and Practice, Vol 2011 (2011) Cardiology Research and Practice |
| ISSN: | 2090-0597 |
| Popis: | atrial fibrillation (AF) is associated with a significant burden of morbidity and increased risk of mortality. Antiarrhythmic drug therapy remains a cornerstone to restore and maintain sinus rhythm for patients with paroxysmal and persistent AF based on current guidelines. However, conventional drugs have limited efficacy, present problematic risks of proarrhythmia and cause significant noncardiac organ toxicity. Thus, inadequacies in current therapies for atrial fibrillation have made new drug development crucial. New antiarrhythmic drugs and new anticoagulant agents have changed the current management of AF. This paper summarizes the available evidence regarding the efficacy of medications used for acute management of AF, rhythm and ventricular rate control, and stroke prevention in patients with atrial fibrillation and focuses on the current pharmacological agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|