Ghrelin level and weight loss after laparoscopic sleeve gastrectomy and gastric mini-bypass for Prader-Willi syndrome in Chinese
| Autor: | Simon Kin Hung Wong, Candice C. H. Lam, Enders K.W. Ng, Anthony K. W. Fong |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Gastroplasty Endocrinology Diabetes and Metabolism Body Mass Index Young Adult Asian People Weight loss Weight Loss Medicine Humans Prospective Studies Young adult Laparoscopy Prospective cohort study Nutrition and Dietetics medicine.diagnostic_test business.industry nutritional and metabolic diseases medicine.disease Obesity Ghrelin Surgery Obesity Morbid Treatment Outcome Iron-deficiency anemia Female medicine.symptom business Body mass index Prader-Willi Syndrome Biomarkers Follow-Up Studies |
| Zdroj: | Obesity surgery. 22(11) |
| ISSN: | 1708-0428 |
| Popis: | Prader-Willi syndrome (PWS) is a chromosomal disorder characterized by the presence of hyperghrelinemia, hyperphagia, and obesity. The optimal treatment for PWS patient remains controversial. Here, we present our experience of treating PWS with laparoscopic mini-gastric bypass (LMGBP) and laparoscopic sleeve gastrectomy (LSG). Three patients with genetic diagnosis of PWS and body mass index (BMI) greater than 40 kg/m(2) were referred for bariatric surgery. All of them had completed 2-year postoperative follow-up. Body weight, BMI, and ghrelin levels were recorded before and after surgery. They were two females and one male. Their age ranged from 15 to 23 years old, and the mean BMI was 46.7 kg/m(2) (range 44-50). Two patients underwent LSG and one patient underwent LMGBP. After a median follow-up of 33 months (range 24-36 months), mean weight loss and percentage of excessive weight loss at 2 years were 32.5 kg (24.9-38.3 kg) and 63.2 % (range 50.5-86.2 %), respectively. The mean fasting active ghrelin level decreased from 1,134.2 pg/ml preoperatively to 519.8 pg/ml 1 year after surgery. No major complication was observed. Iron deficiency anemia was observed in the patient who underwent LMGBP. Significant reduction of body weight and level of serum ghrelin can be achieved with minimal morbidity by LSG or LMGBP in patients with PWS. |
| Databáze: | OpenAIRE |
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