The etiological effect of a new low-frequency ESR1 variant on Mild Cognitive Impairment and Alzheimer’s Disease: a population-based study

Autor:	Wandong Zhang, Hui Juan, Xiaoquan Zhu, Huiping Yuan, Dantao Peng, Fan Yang, Zeping Lv, Luning Wang, Qi Zhou, Xiaoling Li, Ji-ping Tan, Lianqi Cui, Haiqun Xie, Ze Yang, Shige Qi, Liang Sun, Shouzi Zhang, Zhihui Wang, Li-hua Ma, Caiyou Hu
Rok vydání:	2018
Předmět:	Male 0301 basic medicine Apolipoprotein E Aging Disease Polymorphism Single Nucleotide Pathogenesis 03 medical and health sciences chemistry.chemical_compound Apolipoproteins E 0302 clinical medicine Alzheimer Disease Genetic variation Humans Medicine Cognitive Dysfunction Cognitive impairment Aβ Amyloid beta-Peptides ESR1 Cholesterol business.industry Estrogen Receptor alpha cholesterol AD Cell Biology MCI 030104 developmental biology chemistry Immunology Etiology Female business Estrogen receptor alpha 030217 neurology & neurosurgery Research Paper
Zdroj:	Aging (Albany NY)
ISSN:	1945-4589
DOI:	10.18632/aging.101548
Popis:	Latent genetic variations of cholesterol metabolism-related genes in late-onset Alzheimer’s disease, especially, as well as in mild cognitive impairment pathogenesis are still to be studied extensively. Thus, we performed the targeted-sequencing of 12 nuclear receptor genes plus APOE which were involved in cholesterol content modulation to screen susceptible genetic variants and focused on a new risk variant ESR1 rs9340803 at 6q25.1 for both late-onset Alzheimer’s disease (OR=3.30[1.84~4.22], p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90b502c62a8d094b7c632c4e2890ccc https://doi.org/10.18632/aging.101548 Zobrazit plný text záznamu