Observations on the anemia and neutropenia of human copper deficiency
| Autor: | Bernard L. Zidar, Richard K. Shadduck, Alan Winkelstein, Zella R. Zeigler |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Ineffective erythropoiesis medicine.medical_specialty Neutropenia Anemia Reticulocytosis Bone Marrow Cells medicine.disease_cause Granulopoiesis Colony-Stimulating Factors Internal medicine medicine Humans Erythropoietin Cells Cultured business.industry Hematology medicine.disease Hematopoiesis medicine.anatomical_structure Endocrinology Female Bone marrow medicine.symptom Copper deficiency business Myelocyte Copper Agranulocytosis |
| Zdroj: | American Journal of Hematology. 3:177-185 |
| ISSN: | 0361-8609 |
| Popis: | Following extensive bowel resection, a young woman experienced severe malnutrition; subsequent administration of parenteral nutrition precipitated the copper deficiency syndrome. This consisted of hypocupremia, subnormal ceruloplasmin levels, anemia, and severe neutropenia. The bone marrow was megaloblastic, vacuolated, and sideroblastic; granulocytic maturation was not observed beyond the myelocyte stage. Copper sulfate therapy was followed by a marked reticulocytosis, increase in hematocrit, and recovery of neutrophils. Additional studies indicated that both serum and urinary erythropoietin values were low; serum activity increased after copper supplementation. Abnormal granulopoiesis was demonstrated using the in vitro granulocyte colony assay. The patient's granulcoytic stem cells were normal on two occasions; however, mixing studies showed that culture of the patient's copper-deficient marrow with her copper-deficient serum yielded significantly reduced numbers of granulocyte colonies. Thus, copper appears to be a necessary element for normal hematopoiesis; lack of this trace element may result in ineffective erythropoiesis and granulopoiesis. |
| Databáze: | OpenAIRE |
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