Multiple-dose pharmacokinetics of a long half-life drug: contributions of mathematical modeling
| Autor: | B. Robbins, J. Kovarik, J. Meligeni, Jeffrey A. Cramer, Jerry Nedelman, E. Gibiansky |
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| Rok vydání: | 1997 |
| Předmět: |
Drug
Adult Physiologically based pharmacokinetic modelling media_common.quotation_subject Pharmacology Multiple dose Models Biological Drug Administration Schedule Pharmacokinetics Healthy volunteers Medicine Humans Pharmacology (medical) In patient Mathematical Computing media_common Aged Clinical Trials as Topic Safety studies business.industry Body Fluid Compartments Middle Aged NONMEM business Half-Life |
| Zdroj: | European journal of drug metabolism and pharmacokinetics. 22(2) |
| ISSN: | 0378-7966 |
| Popis: | A mathematical model was found that consistently described diverse pharmacokinetic data for a development compound from three pharmacokinetic studies in healthy volunteers and two efficacy and safety studies in patients. The model provided: quantification of demographic and random sources of pharmacokinetic variability; estimation of important pharmacokinetic parameters from sparse data; and explanation of observed patterns of pharmacokinetic response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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