fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history

Autor: Laura L. Peoples, D. Bruce Vaupel, Karine Guillem, Anna Moore, Hanbing Lu, Svetlana I. Chefer, Elliot A. Stein, Yihong Yang, Thomas J. Ross, Pradeep K. Kurup
Přispěvatelé: Ahmed, Serge, Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2012
Předmět:
Sucrose
medicine.medical_specialty
Cognitive Neuroscience
media_common.quotation_subject
[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Prefrontal Cortex
Self Administration
Brain mapping
Article
Cocaine-Related Disorders
03 medical and health sciences
0302 clinical medicine
Cocaine
Dopamine Uptake Inhibitors
Internal medicine
Neuroplasticity
medicine
Animals
Rats
Long-Evans
Prefrontal cortex
Anterior cingulate cortex
030304 developmental biology
media_common
Brain Mapping
0303 health sciences
Neuronal Plasticity
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
medicine.diagnostic_test
Addiction
Abstinence
Magnetic Resonance Imaging
Rats
Disease Models
Animal
Endocrinology
medicine.anatomical_structure
Neurology
Self-administration
Functional magnetic resonance imaging
Psychology
Neuroscience
030217 neurology & neurosurgery
Zdroj: NeuroImage
NeuroImage, Elsevier, 2012, 62, pp.1857-66
ISSN: 1053-8119
1095-9572
DOI: 10.1016/j.neuroimage.2012.05.076
Popis: International audience; Repeated cocaine exposure induces long-lasting neuroadaptations that alter subsequent responsiveness to the drug. However, systems-level investigation of these neuroplastic consequences is limited. We employed a rodent model of drug addiction to investigate neuroadaptations associated with prolonged forced abstinence after long-term cocaine self-administration (SA). Since natural rewards also activate the mesolimbic reward system in a partially overlapping fashion as cocaine, our design also included a sucrose SA group. Rats were trained to self-administer cocaine or sucrose using a fixed-ratio one, long-access schedule (6 h/day for 20 days). A third group of naïve, sedentary rats served as a negative control. After 30 days of abstinence, the reactivity of the reward system was assessed with functional magnetic resonance imaging (fMRI) following an intravenous cocaine injection challenge. A strong positive fMRI response, as measured by fractional cerebral blood volume changes relative to baseline (CBV%), was seen in the sedentary control group in such cortico-limbic regions as medial prefrontal cortex and anterior cingulate cortex. In contrast, both the cocaine and sucrose SA groups demonstrated a very similar initial negative fMRI response followed by an attenuated positive response. The magnitude of the mPFC response was significantly correlated with the total amount of reinforcer intake during the training sessions for the cocaine SA but not for the sucrose SA group. Given that the two SA groups had identical histories of operant training and handling, this region-specific group difference revealed by regression analysis may reflect the development of neuroadaptive mechanisms specifically related to the emergence of addiction-like behavior that occurs only in cocaine SA animals.
Databáze: OpenAIRE
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