Surgical results and long-term follow-up of T4-non-small cell lung cancer invading the left atrium or the intrapericardial base of the pulmonary veins

Autor: Alessandro Bini, Fabio Davoli, Giampiero Dolci, Nicola Cassanelli, Guido Caroli, Andrea Dell’Amore, Giulia Luciano, Franco Stella
Přispěvatelé: Stella F., Dell'Amore A., Caroli G., Dolci G., Cassanelli N., Luciano G., Davoli F., Bini A.
Rok vydání: 2012
Předmět:
Male
Lung Neoplasms
Time Factors
medicine.medical_treatment
Extended resection
Left atrium
Lung cancer
Pulmonary veins
Adult
Aged
Aged
80 and over
Carcinoma
Non-Small-Cell Lung
Female
Heart Atria
Hospital Mortality
Humans
Italy
Kaplan-Meier Estimate
Logistic Models
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Patient Selection
Proportional Hazards Models
Pulmonary Veins
Retrospective Studies
Risk Assessment
Risk Factors
Survival Rate
Tomography
X-Ray Computed
Treatment Outcome
Pneumonectomy
Disease
80 and over
Non-Small-Cell Lung
Tomography
Cause of death
X-Ray Computed
medicine.anatomical_structure
Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Institutional Reports
medicine
Survival rate
Proportional hazards model
business.industry
Carcinoma
Retrospective cohort study
medicine.disease
locally advanced NSCLC
Surgery
business
Zdroj: Interactive CardioVascular and Thoracic Surgery. 14:415-419
ISSN: 1569-9285
1569-9293
DOI: 10.1093/icvts/ivr160
Popis: Patients with locally advanced non-small cell lung cancer infiltrating the left atrium (LA) or the intrapericardial base of the pulmonary veins (PVs) are generally not considered good candidates for surgery because of the poor long-term survival. In the last 10 years, 31 consecutive patients with non-small cell lung cancer directly invading the LA or the intrapericardial base of the PVs underwent surgery. Pneumonectomy was the operation performed most frequently. In-hospital mortality was 9.7% and overall morbidity was 52%. One-, 2- and 3-year survival rates were 64, 46 and 30%, respectively with a mean survival of 22 months. The systemic recurrence of disease was the major cause of death at follow-up. At statistical analyses, the N-factor and the type of operation were related to poor long-term survival. In these patients, surgery could be performed with an acceptable operative mortality and morbidity. Surgery should be considered whenever a complete resection is technically possible. A careful preoperative evaluation is mandatory to select good candidates for surgery.
Databáze: OpenAIRE
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