Neurodevelopmental Impairment at Two Years in Premature Infants with Prolonged Patency of Ductus Arteriosus after a Conservative Approach
| Autor: | Victoria Aldecoa-Bilbao, Maria-Jesús García-Catalán, Carme Figaró Voltà, Marta Gaixa, Silvia Teodoro, Jordi Clotet Caba |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Conservative management Gestational Age Ibuprofen Conservative Treatment law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law 030225 pediatrics Ductus arteriosus Infant Mortality medicine Humans 030212 general & internal medicine Prospective Studies Surgical treatment Ductus Arteriosus Patent business.industry Infant Newborn Obstetrics and Gynecology Infant Conservative treatment medicine.anatomical_structure Treatment Outcome Neurodevelopmental Disorders Spain Child Preschool Pediatrics Perinatology and Child Health Cohort Multivariate Analysis Gestation Regression Analysis Female business Infant Premature medicine.drug |
| Zdroj: | American journal of perinatology. 38(5) |
| ISSN: | 1098-8785 |
| Popis: | Objective The study aims to assess the impact on neurodevelopmental outcomes of a prolonged hemodynamically significant patent ductus arteriosus (PDA) after a conservative treatment.Study Design This involves the study of two cohorts of preterm infants 23 to 29 weeks gestation, before (n = 29) and after (n = 54) a conservative approach of PDA. We compared survival, major outcomes, and neurodevelopmental impairment (NDI) at 2 years and analyzed NDI in the conservative cohort according to the duration of the PDA.Results Conservative cohort received less medical (31.5%) and surgical treatment (7.4%) and had more days of PDA (59 days in 24–26 weeks and 22 days in 27–29 weeks; p 28 days was not related to worse outcomes at discharge (p = 0.296) or less survival-without-NDI at 2 years (p = 0.498).Conclusion Until randomized trials prove the benefit of attempting to close the PDA with ibuprofen in the first week of life, conservative management may be a reasonable option. |
| Databáze: | OpenAIRE |
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