Long-term effects on testicular function of high-dose testosterone treatment for excessively tall stature
| Autor: | Eberhard Nieschlag, J Zentgraf, S Kliesch, B. Lemcke, Hermann M. Behre, J H Bramswig |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Varicocele Reproductive medicine Semen Semen analysis Biochemistry Endocrinology Internal medicine Cryptorchidism Testis medicine Humans Testosterone Ultrasonography medicine.diagnostic_test business.industry Biochemistry (medical) Tall Stature Luteinizing Hormone medicine.disease Sperm Body Height Cross-Sectional Studies Sperm Motility Follicle Stimulating Hormone business Hormone |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 81(1) |
| ISSN: | 0021-972X |
| Popis: | High-dose testosterone treatment is applied during puberty to reduce the predicted adult height in excessively tall boys. To date it has remained unclear whether this therapy produces any long-term effects on reproductive functions of the patients. To clarify this question, we performed a follow-up study in 47 tall men, determining seminal and hormonal parameters 10.6 +/- 2.5 years (mean +/- SD) after cessation of therapy. The tall men treated were compared with 123 normal men attending the Institute of Reproductive Medicine as volunteers for various clinical studies. Clinical examination revealed a significantly higher prevalence of varicoceles and history of maldescended testes in the testosterone-treated tall men compared with the controls. Semen analysis revealed significantly lower progressive motility in the tall men compared with the normal men (49.2 +/- 13.4 vs. 54.3 +/- 12.8%). A nonsignificant tendency towards lower sperm concentration (43.8 +/- 35.4 vs. 57.8 +/- 45.6 mL/mL), lower total sperm count (184.4 +/- 158.0 vs. 225.4 +/- 277.5 mL/ejaculate), and reduced normal sperm morphology (27.6 +/- 12.5 vs. 30.9 +/- 13.1%) was evident in the testosterone-treated tall men. Although there was no difference in testicular volume and FSH between the groups, testosterone was lower in the testosterone-treated tall men (19.9 +/- 7.4 vs. 23.9 +/- 7.0 nmol/L). Statistical analysis of the subgroups of testosterone-treated tall men and control men without varicocele and cryptorchidism revealed no differences in any ejaculate parameter. The small difference in semen variables may be explained by a higher prevalence of varicocele and maldescended testes in the testosterone-treated tall men. |
| Databáze: | OpenAIRE |
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