Proteome-based identification of apolipoprotein A-IV as an early diagnostic biomarker in liver fibrosis
| Autor: | Mu-Hong Chen, Pei-Wen Wang, Tung-Ho Wu, Yu-Ching Hung, Chau-Ting Yeh, Tai-Long Pan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology Apolipoprotein B Liver fibrosis proteome Traditional Chinese medicine Apolipoprotein A-IV Gastroenterology 03 medical and health sciences APOA4 0302 clinical medicine Internal medicine medicine Diagnostic biomarker hepatic fibrosis ApoA4 network analysis biology business.industry 030104 developmental biology Oncology biology.protein Biomarker (medicine) 030211 gastroenterology & hepatology dimethylnitrosamine Hepatic fibrosis business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Pei-Wen Wang 1, * , Yu-Ching Hung 2, 3, * , Tung-Ho Wu 4, * , Mu-Hong Chen 5, 6 , Chau-Ting Yeh 7 and Tai-Long Pan 3, 7, 8, 9 1 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan 2 Department of Chinese Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan 3 School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan 4 Division of Cardiovascular Surgery, Veterans General Hospital, Kaohsiung, Taiwan 5 Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan 6 Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan 7 Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan 8 Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan 9 Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan * These authors have contributed equally to this work Correspondence to: Tai-Long Pan, email: pan@mail.cgu.edu.tw Chau-Ting Yeh, email: chautingy@gmail.com Keywords: hepatic fibrosis, proteome, dimethylnitrosamine, ApoA4, network analysis Received: July 26, 2017 Accepted: August 28, 2017 Published: October 06, 2017 ABSTRACT Hepatic fibrosis may ultimately result in organ failure and death, a reality compounded by the fact that most drugs for liver fibrosis appear to be effective only if given as a prophylactic or early treatment. In a dimethylnitrosamine-induced liver fibrotic model, aspartate aminotransferase/alanine aminotransferase levels could not precisely distinguish the differences between the initial stage of liver fibrosis and normal control, whereas histological examination indicated that dimethylnitrosamine treatment for two weeks has resulted in hepatic fibrogenesis. Comprehensive proteomics identified 12 proteins mainly associated with the interleukin 6-stimulated inflammatory pathway. Coordinately, cytokine profiles showed that dimethylnitrosamine administration would stimulate various signaling pathways leading to liver fibrosis. Of note, apolipoprotein A4 in serum samples obtained from patients in the early stage of liver fibrosis were significantly increased compared to the healthy controls ( p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|